ArticleScientific reports2016
In vitro and in vivo study of additive manufactured porous Ti6Al4V scaffolds for repairing bone defects.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
75 citing papers in PubMed, 1 synthesis or guideline pooled it.
- 3D-printed porous Ti6Al4V scaffolds for long bone repair in animal models: a systematic review.Journal of orthopaedic surgery and research · 2022Pooled it
- Digital Design of Kurtosis-Controlled Ti-6Al-4V Lattices for Patient-Specific Orthopedic Implants: A Computational Framework.Bioengineering (Basel, Switzerland) · 2026Article
- An Experimental Study on 3D-Printed Gyroid-Shaped TC4 Porous Scaffolds Guiding Angiogenesis and Osteogenesis in Bone Defect Areas.ACS biomaterials science & engineering · 2026Article
- Biomimetic Architectural Cover Accelerates Osseointegration of Titanium Implants.Journal of bone metabolism · 2026Article
- 3D-Printed Poly (l-lactic acid) Scaffolds for Bone Repair with Oriented Hierarchical Microcellular Foam Structure and Biocompatibility.Biomolecules · 2025Article
- Spatially distributed and interconnected porous architectures for dental implants.International journal of implant dentistry · 2025Article
- Article
- 3D-printed hip prostheses with regenerative integration: a state-of-the-art comprehensive review.Frontiers in bioengineering and biotechnology · 2025Review
- Finite element analysis of the biomechanical behavior of four osseointegrated prosthetic designs.Frontiers in bioengineering and biotechnology · 2025Article
- Nickel-titanium alloy porous scaffolds based on a dominant cellular structure manufactured by laser powder bed fusion have satisfactory osteogenic efficacy.Materials today. Bio · 2024Article
- Comparative analysis of conventionally and additively manufactured acetabular shells from a single manufacturer.3D printing in medicine · 2024Article
- Comparison In Vitro Study on the Interface between Skin and Bone Cell Cultures and Microporous Titanium Samples Manufactured with 3D Printing Technology Versus Sintered Samples.Nanomaterials (Basel, Switzerland) · 2024Article
- In Vivo Assessment of a Triple Periodic Minimal Surface Based Biomimmetic Gyroid as an Implant Material in a Rabbit Tibia Model.ACS materials Au · 2024Article
- Increased stability of short femoral stem through customized distribution of coefficient of friction in porous coating.Scientific reports · 2024Article
- New Innovation: Custom Titanium Zygomaticomaxillary Complex (ZMC) Plate for Facial Reconstruction.Cureus · 2024Article
- Internal surface modification of additively manufactured macroporous TiAl6V4 biomimetic implants via a calciothermic reaction-based process and osteogenic in vivo responses.Journal of biomedical materials research. Part B, Applied biomaterials · 2024Article
- Three-Dimensional Printed Hydroxyapatite Bone Substitutes Designed by a Novel Periodic Minimal Surface Algorithm Are Highly Osteoconductive.3D printing and additive manufacturing · 2023Article
- Study of the Effect of Anodic Oxidation on the Corrosion Properties of the Ti6Al4V Implant Produced from SLM.Journal of functional biomaterials · 2023Article
- Article
- Titanium Lattice Structures Produced via Additive Manufacturing for a Bone Scaffold: A Review.Journal of functional biomaterials · 2023Review
15 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metallic implants with a low effective modulus can provide early load-bearing and reduce stress shielding, which is favorable for increasing in vivo life-span. In this research, porous Ti6Al4V scaffolds with three pore sizes (300~400, 400~500, and 500~700 μm) were manufactured by Electron Beam Melting, with an elastic modulus range of 3.7 to 1.7 GPa. Cytocompatibility in vitro and osseointegration ability in vivo of scaffolds were assessed. hBMSCs numbers increased on all porous scaffolds over time. The group with intended pore sizes of 300 to 400 μm was significantly higher than that of the other two porous scaffolds at days 5 and 7. This group also had higher ALP activity at day 7 in osteogenic differentiation experiment. The scaffold with pore size of 300 to 400 μm was implanted into a 30-mm segmental defect of goat metatarsus. In vivo evaluations indicated that the depth of bone ingrowth increased over time and no implant dislocation occurred during the experiment. Based on its better cytocompatibility and favorable bone ingrowth, the present data showed the capability of the additive manufactured porous Ti6Al4V scaffold with an intended pore size of 300 to 400 μm for large segmental bone defects.
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Registered trials
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