ArticleNeuron2016
CaMKII Phosphorylation of TARPγ-8 Is a Mediator of LTP and Learning and Memory.
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Article in Neuron, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.
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77citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
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Who cites it
77 citing papers in PubMed, 124 citations in OpenAlex.
- Transmembrane AMPA receptor regulatory protein TARP ɣ-8 is a target of ethanol that regulates self-administration and relapse in mice.Psychopharmacology · 2026Article
- Sex differences in AMPA receptor trafficking proteins.Biology of sex differences · 2026Review
- GARLH regulates neuroligin preference for excitatory versus inhibitory synapses.The Journal of cell biology · 2026Article
- AMPA Receptors in Synaptic Plasticity, Memory Function, and Brain Diseases.Cellular and molecular neurobiology · 2025Review
- Article
- A revised view of the role of CaMKII in learning and memory.Nature neuroscience · 2025Review
- LTP expression mediated by autonomous activity of GluN2B-bound CaMKII.Cell reports · 2024Article
- Alternative translation initiation produces synaptic organizer proteoforms with distinct localization and functions.Molecular cell · 2024Article
- Activity-dependent diffusion trapping of AMPA receptors as a key step for expression of early LTP.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Tuning synaptic strength by regulation of AMPA glutamate receptor localization.BioEssays : news and reviews in molecular, cellular and developmental biology · 2024Review
- Article
- Celebrating the Birthday of AMPA Receptor Nanodomains: Illuminating the Nanoscale Organization of Excitatory Synapses with 10 Nanocandles.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- Rem2 interacts with CaMKII at synapses and restricts long-term potentiation in hippocampus.bioRxiv : the preprint server for biology · 2024Article
- Alternative translation initiation produces synaptic organizer proteoforms with distinct localization and functions.bioRxiv : the preprint server for biology · 2024Article
- Activity-Dependent Stabilization of Nascent Dendritic Spines Requires Nonenzymatic CaMKIIα Function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Rem2 interacts with CaMKII at synapses and restricts long-term potentiation in hippocampus.PloS one · 2024Article
- Rapid sequential clustering of NMDARs, CaMKII, and AMPARs upon activation of NMDARs at developing synapses.Frontiers in synaptic neuroscience · 2024Article
- Synaptic memory and CaMKII.Physiological reviews · 2023Review
- Article
- Chemogenetic regulation of the TARP-lipid interaction mimics LTP and reversibly modifies behavior.Cell reports · 2023Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 2 countries.
Joongkyu ParkDepartment of Cellular and Molecular Physiology, Program in Cellular Neuroscience, Neurodegeneration, and Repair, Department of Neuroscience, Yale University School of Medicine, New Haven, CT 06520, USA; Kavli Institute for Neuroscience, Yale University School of Medicine, New Haven, CT 06520, USA.
Andrés E ChávezDominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Centro Interdisciplinario de Neurociencia de Valparaíso, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso 2340000, Chile.
Yann S MineurKavli Institute for Neuroscience, Yale University School of Medicine, New Haven, CT 06520, USA; Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06520, USA.
Megumi Morimoto-TomitaDepartment of Cellular and Molecular Physiology, Program in Cellular Neuroscience, Neurodegeneration, and Repair, Department of Neuroscience, Yale University School of Medicine, New Haven, CT 06520, USA; Kavli Institute for Neuroscience, Yale University School of Medicine, New Haven, CT 06520, USA.
Stefano LutzuDominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Kwang S KimDepartment of Cellular and Molecular Physiology, Program in Cellular Neuroscience, Neurodegeneration, and Repair, Department of Neuroscience, Yale University School of Medicine, New Haven, CT 06520, USA; Kavli Institute for Neuroscience, Yale University School of Medicine, New Haven, CT 06520, USA.
Marina R PicciottoKavli Institute for Neuroscience, Yale University School of Medicine, New Haven, CT 06520, USA; Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06520, USA.
Pablo E CastilloDominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Electronic address: pablo.castillo@einstein.yu.edu.
Susumu TomitaDepartment of Cellular and Molecular Physiology, Program in Cellular Neuroscience, Neurodegeneration, and Repair, Department of Neuroscience, Yale University School of Medicine, New Haven, CT 06520, USA; Kavli Institute for Neuroscience, Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address: susumu.tomita@yale.edu.
Yale University · USAlbert Einstein College of Medicine · USUniversity of Valparaíso · CL
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MYale/NIDA Neuroproteomics Research CenterP30DA018343 · NIDA · YALE UNIVERSITY · PI Marina R Picciotto · 2004 to 2026
$37.1MUC Davis/NIH NeuroMab FacilityU24NS050606 · NINDS · UNIVERSITY OF CALIFORNIA DAVIS · PI TRIMMER, JAMES S · 2005 to 2014
$15.6MCholinergic Contribution to Circuits Underlying DepressionR01MH077681 · NIMH · YALE UNIVERSITY · PI MINEUR, YANN SEBASTIEN, PICCIOTTO, MARINA R · 2006 to 2025
$7.0MAnatomical basis for nicotine addiction in miceR01DA014241 · NIDA · YALE UNIVERSITY · PI PICCIOTTO, MARINA R · 2001 to 2018
$5.2MRegulation of glutamate receptors by calcium-dependent protein kinasesR01MH077939 · NIMH · YALE UNIVERSITY · PI TOMITA, SUSUMU · 2008 to 2023
$5.2MPresynaptic Forms of Long-Term Plasticity in the CNSR01DA017392 · NIDA · YESHIVA UNIVERSITY · PI CASTILLO, PABLO E · 2003 to 2019
$4.5MActivity-dependent synaptic plasticity expressed by NMDARsR01MH081935 · NIMH · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI CASTILLO, PABLO E · 2008 to 2018
$4.0MAnatomical Basis for Nicotine AddictionR37DA014241 · NIDA · YALE UNIVERSITY · PI Marina R Picciotto · 2020 to 2026
$2.7MRegulation of glutamate receptors by calcium-dependent protein kinaseR56MH077939 · NIMH · YALE UNIVERSITY · PI TOMITA, SUSUMU · 2013 to 2014
$833kCholinergic Pathways in DepressionR03MH105824 · NIMH · YALE UNIVERSITY · PI MINEUR, YANN SEBASTIEN · 2015 to 2016
$167kNCATS NIH HHS UL1 TR001863NIDA NIH HHS P30 DA018343NIDA NIH HHS R01 DA014241NIDA NIH HHS R01 DA017392NIDA NIH HHS R37 DA014241NIMH NIH HHS R01 MH077681NIMH NIH HHS R01 MH077939NIMH NIH HHS R01 MH081935NIMH NIH HHS R03 MH105824NIMH NIH HHS R56 MH077939NINDS NIH HHS U24 NS050606
Abstract
Protein phosphorylation is an essential step for the expression of long-term potentiation (LTP), a long-lasting, activity-dependent strengthening of synaptic transmission widely regarded as a cellular mechanism underlying learning and memory. At the core of LTP is the synaptic insertion of AMPA receptors (AMPARs) triggered by the NMDA receptor-dependent activation of Ca
Indexed as
AnimalsCalcium-Calmodulin-Dependent Protein Kinase Type 2Calcium ChannelsHippocampusLearningLong-Term PotentiationMemoryMiceMice, KnockoutPhosphorylationReceptors, AMPACalcium-Calmodulin-Dependent Protein Kinase Type 2Calcium ChannelsReceptors, AMPATARP gamma-8 protein, mouse
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.