ArticleThe Annals of thoracic surgery2017
Serial Lactate Measurements as a Prognostic Tool in Venovenous Extracorporeal Membrane Oxygenation Support.
Article in The Annals of thoracic surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Is Extracorporeal Membrane Oxygenation the Standard Care for Acute Respiratory Distress Syndrome: A Systematic Review and Meta-Analysis.Heart, lung & circulation · 2021Pooled it
- Efficacy of Veno-Arterial Extracorporeal Life Support in Adult Patients with Refractory Cardiogenic Shock.Clinical medicine insights. Circulatory, respiratory and pulmonary medicine · 2022Article
- Outcomes of patients with acute respiratory failure on veno-venous extracorporeal membrane oxygenation requiring additional circulatory support by veno-venoarterial extracorporeal membrane oxygenation.Frontiers in medicine · 2022Article
- Electrodiagnostic findings in patients with non-COVID-19- and COVID-19-related acute respiratory distress syndrome.Acta neurologica Scandinavica · 2021Article
- Article
- [ECMO treatment in acute lung failure : Who profits?]Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2020Review
- Hemodynamic monitoring in patients with venoarterial extracorporeal membrane oxygenation.Annals of translational medicine · 2020Review
- Transportation of patients with severe respiratory failure on ECMO support. Four-year experience of a single ECMO center.Anaesthesiology intensive therapy · 2020Article
- Extracorporeal Cardiopulmonary Resuscitation: One-Year Survival and Neurobehavioral Outcome Among Infants and Children With In-Hospital Cardiac Arrest.Critical care medicine · 2019Article
- Risk stratification for severe acute respiratory distress syndrome requiring veno venous extracorporeal membrane oxygenation: a clinical need.Journal of thoracic disease · 2018Article
- Inflammation in venovenous extracorporeal membrane oxygenation: villain or innocent bystander?Journal of thoracic disease · 2018Article
- What about prognostic outcome parameters in patients with acute respiratory distress syndrome (ARDS) treated with veno-venous extracorporeal membrane oxygenation (VV-ECMO)?Journal of thoracic disease · 2018Article
- Bilirubin in the early course of venovenous extracorporeal membrane oxygenation support for refractory ARDS.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2018Observational
- Early changes in coagulation profiles and lactate levels in patients with septic shock undergoing extracorporeal membrane oxygenation.Journal of thoracic disease · 2018Article
- Comparison of mortality prediction models in acute respiratory distress syndrome undergoing extracorporeal membrane oxygenation and development of a novel prediction score: the PREdiction of Survival on ECMO Therapy-Score (PRESET-Score).Critical care (London, England) · 2017Article
- Functional Status of Neonatal and Pediatric Patients After Extracorporeal Membrane Oxygenation.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2017Observational
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10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSerial lactate measurements over time or lactate clearance has been reported to be clinically reliable for risk stratification in different pathologic conditions ranging from sepsis to trauma, but no data are so far available on the behavior of lactate during venovenous extracorporeal membrane oxygenation (VV-ECMO) support in refractory adult acute respiratory distress syndrome (ARDS).
methodsWe assessed lactate values during VV-ECMO support and the prognostic role of lactate clearance at 6, 24, and 72 hours after ECMO start in 126 consecutive patients with refractory ARDS treated with VV-ECMO.
resultsSurvivors showed a progressive, significant decrease in lactate values throughout the study period, whereas nonsurvivors exhibited a progressive increase. Lactate values (measured before ECMO initiation, as well as 6 and 24 hours after) were independently associated with intensive care unit (ICU) death. A significantly higher lactate clearance was observed for survivors at 72 hours after ECMO start than for nonsurvivors. At logistic regression analysis, lactate clearance at 72 hours after ECMO start was an independent predictor of ICU death (odds ratio 0.988, 95% confidence interval [CI]: 0.995 to 0.982, p = 0.001) (together with age, body mass index, and Sequential Organ Failure Assessment). At receiver operating characteristic curve analysis, lactate clearance at 72 hours after ECMO start cutoff value of -16% had a sensitivity of 68% and a specificity of 63% (area under the curve = 0.67, 95% CI: 0.57 to 0.77, p = 0.002).
conclusionsLactate (measured before ECMO initiation, as well as 6 and 24 hours after) is a prognostic factor in patients with refractory ARDS treated with VV-ECMO, and lactate clearance at 72 hours after ECMO initiation helps in the risk stratification of these patients, being independently associated with death.
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