ArticleJournal of periodontology2017
Decrease of Pericytes is Associated With Liver Disease Caused by Ligature-Induced Periodontitis in Rats.
Article in Journal of periodontology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- The potential association between periodontitis and non-alcoholic fatty liver disease: a systematic review.Clinical oral investigations · 2018Pooled it
- Lactobacillus sp. attenuates oral and hepatic alterations and decreases caspase-8 expression in ligature-induced periodontitis.Journal of applied oral science : revista FOB · 2026Article
- Expression of caspase-8 in non-alcoholic fatty liver disease related to ligature-induced periodontitis in rats.Journal of applied oral science : revista FOB · 2026Article
- Proteomics reveals periodontitis-driven oxidative stress and lipid metabolism disruption in NAFLD.Frontiers in endocrinology · 2025Article
- Development of liver disease caused by chronic periodontitis in rats.Journal of applied oral science : revista FOB · 2025Article
- Hepatitis B infection is associated with periodontitis: the national health and nutrition examination survey (2009-2014).BMC oral health · 2024Article
- Multifunctional role of oral bacteria in the progression of non-alcoholic fatty liver disease.World journal of hepatology · 2024Review
- Sirt6 Activation Ameliorates Inflammatory Bone Loss in Ligature-Induced Periodontitis in Mice.International journal of molecular sciences · 2023Article
- Effect of peroxisome proliferator-activated receptor-γ coactivator-1α on liver injury induced by periodontitis in rats.Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2021Article
- Periodontal disease-related nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: An emerging concept of oral-liver axis.Periodontology 2000 · 2021Review
- Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities.Nature reviews. Immunology · 2021Review
- The role of TLR4/MyD88/NF-κB pathway in periodontitis-induced liver inflammation of rats.Oral diseases · 2021Article
- Relationship between NAFLD and Periodontal Disease from the View of Clinical and Basic Research, and Immunological Response.International journal of molecular sciences · 2021Review
- Periodontitis causes abnormalities in the liver of rats.Journal of periodontology · 2019Article
- One or two ligatures inducing periodontitis are sufficient to cause fatty liver.Medicina oral, patologia oral y cirugia bucal · 2018Article
- Association of liver enzyme levels and alveolar bone loss: A cross-sectional clinical study in Sado Island.Journal of clinical and experimental dentistry · 2018Article
- Genetic Factors and the Risk of Periodontitis Development: Findings from a Systematic Review Composed of 13 Studies of Meta-Analysis with 71,531 Participants.International journal of dentistry · 2017Review
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundDamage caused by periodontitis not only affects periodontal tissues, but also increases the severity of various illnesses such as rheumatoid arthritis, diabetes, and liver diseases. The aim of this study is to investigate the association between induced periodontitis and damage caused through its systemic effects on the liver.
methodsTwenty rats were divided into two groups: control and periodontitis. The following parameters were evaluated: gingival bleeding index (GBI), probing depth (PD), myeloperoxidase (MPO) activity, alveolar bone loss (ABL) for periodontal tissues; histopathologic examination of gingival and liver tissues; immunohistochemistry to cells positive for neural/glial antigen 2 (NG2) expressed in hepatic pericytes, glutathione (GSH), and malondialdehyde (MDA) concentrations in liver; and serum levels of alanine aminotransferase and aspartate aminotransferase.
resultsGBI, PD, MPO, ABL, and histopathologic examinations demonstrated the development of periodontitis. There was a significant increase in microvesicular steatosis accompanied by a marked reduction in NG2+ pericytes in the periodontitis group compared with the control group. The periodontitis group had significantly lower GSH and higher MDA concentration in the liver compared with the control group.
conclusionsThe present study results link the systemic effects of induced periodontitis with changes in hepatic tissues such as microvesicular steatosis, likely caused by an increase in oxidative stress and lipid peroxidation. The findings from the present study implicate an association between a decrease of pericytes and liver disease caused by ligature-induced periodontitis in rats.
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