Evidence map›Paper›PMID 27666389›Full record

ArticleNature communications2016

FHF-independent conduction of action potentials along the leak-resistant cerebellar granule cell axon.

Katarzyna Dover, Christopher Marra, Sergio Solinas, Marko Popovic, Sathyaa Subramaniyam, Dejan Zecevic, Egidio D'Angelo, Mitchell Goldfarb

Abstract read
In one paragraph

Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Axonal NaScience advances · 2020
    Article
  8. Article
  9. Article
  10. Article
  11. The Axon Initial Segment: An Updated Viewpoint.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018
    Review
  12. Article
  13. Hebbian Spike-Timing Dependent Plasticity at the Cerebellar Input Stage.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Katarzyna DoverDepartment of Biological Sciences, Hunter College of City University, 695 Park Avenue, New York, New York 10065, USA.
Christopher MarraDepartment of Biological Sciences, Hunter College of City University, 695 Park Avenue, New York, New York 10065, USA.
Sergio SolinasBrain Connectivity Center, C. Mondino National Neurological Institute, Via Forlanini 6, Pavia 27100, Italy.
Marko PopovicDepartment of Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06510, USA.
Sathyaa SubramaniyamDepartment of Brain and Behavioral Science, University of Pavia, Via Forlanini 6, Pavia 27100, Italy.
Dejan ZecevicDepartment of Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06510, USA.
Egidio D'AngeloBrain Connectivity Center, C. Mondino National Neurological Institute, Via Forlanini 6, Pavia 27100, Italy.
Mitchell GoldfarbDepartment of Biological Sciences, Hunter College of City University, 695 Park Avenue, New York, New York 10065, USA.

Funding

UC Davis/NIH NeuroMab FacilityU24NS050606 · NINDS · UNIVERSITY OF CALIFORNIA DAVIS · PI TRIMMER, JAMES S · 2005 to 2014
$15.6M
Electrical role of dendritic spinesR01MH106906 · NIMH · YALE UNIVERSITY · PI ZECEVIC, DEJAN P · 2015 to 2019
$2.0M
VGSC Modulation by FHFs: Neural Functions and MechanismsR01GM098540 · NIGMS · HUNTER COLLEGE · PI GOLDFARB, MITCHELL · 2011 to 2014
$1.1M
NIGMS NIH HHS R01 GM098540NIMH NIH HHS R01 MH106906NINDS NIH HHS U24 NS050606
6 · The paper itself

Abstract

Neurons in vertebrate central nervous systems initiate and conduct sodium action potentials in distinct subcellular compartments that differ architecturally and electrically. Here, we report several unanticipated passive and active properties of the cerebellar granule cell's unmyelinated axon. Whereas spike initiation at the axon initial segment relies on sodium channel (Na

Identifiers

PMID27666389
PMCPMC5052690

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.