Evidence map›Paper›PMID 27666329›Full record

Trial reportActa paediatrica (Oslo, Norway : 1992)2017

Pilot study demonstrates that salivary oxytocin can be measured unobtrusively in preterm infants.

D R Kommers, Mac Broeren, P Andriessen, S G Oei, L Feijs, S Bambang Oetomo

Open access · hybridAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Acta paediatrica (Oslo, Norway : 1992), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

D R KommersDepartment of Neonatology, Máxima Medical Centre, Veldhoven, The Netherlands.
Mac BroerenClinical Chemistry Laboratory, Máxima Medical Centre, Veldhoven, The Netherlands.
P AndriessenDepartment of Neonatology, Máxima Medical Centre, Veldhoven, The Netherlands.
S G OeiDepartment of Electrical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.
L FeijsDepartment of Industrial Design, Eindhoven University of Technology, Eindhoven, The Netherlands.
S Bambang OetomoDepartment of Neonatology, Máxima Medical Centre, Veldhoven, The Netherlands.
Radboud University Nijmegen · NLEindhoven University of Technology · NLMáxima Medisch Centrum · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimThis study assessed the feasibility and obtrusiveness of measuring salivary oxytocin in preterm infants receiving Kangaroo care, because this is a period of maximal bonding or co-regulation. We also analysed possible influential determinants, including maternal oxytocin.

methodsThe saliva of preterm infants and their mothers was collected prior to, and during, Kangaroo care using cotton swabs and pooled into vials until sufficient volumes were obtained to measure oxytocin levels using a radioimmunoassay. The obtrusiveness of the infants' collections was measured with a Likert scale.

resultsSaliva was collected unobtrusively prior to, and during, 30 Kangaroo care sessions in 21 preterm infants. This resulted in three vials with sufficient volumes of before-Kangaroo care saliva and three with during-Kangaroo care saliva. Oxytocin was detectable in all six vials. The Kangaroo care duration and the intensity of the mother-infant interaction before and during Kangaroo care seemed to be the most important determinants, and these should preferably be standardised in any future trials.

conclusionOxytocin was measured unobtrusively in the pooled saliva of preterm infants both before and during Kangaroo care and could therefore be investigated as a biomarker in future studies.

Indexed as

Kangaroo-Mother Care MethodAdultBiomarkersFeasibility StudiesFemaleHumansInfant, NewbornInfant, PrematureOxytocinPilot ProjectsRadioimmunoassaySalivaBiomarkersOxytocinBondingCo-regulationKangaroo careOxytocinPreterm infants

Identifiers

PMID27666329
PMCPMC5215538
OpenAlexW2526851147

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.