ArticleThe American journal of cardiology2016
Relation of Pericardial Fat, Intrathoracic Fat, and Abdominal Visceral Fat With Incident Atrial Fibrillation (from the Framingham Heart Study).
Article in The American journal of cardiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Body mass index, abdominal fatness, fat mass and the risk of atrial fibrillation: a systematic review and dose-response meta-analysis of prospective studies.European journal of epidemiology · 2017Pooled it
- Quantitative CT assessment of intrathoracic visceral fat depots and their association with incident heart failure in asymptomatic adults.Frontiers in cardiovascular medicine · 2026Article
- Adiposity-associated atrial fibrillation: molecular determinants, mechanisms, and clinical significance.Cardiovascular research · 2023Review
- Imaging-based body fat depots and new-onset atrial fibrillation in general population: a prospective cohort study.BMC medicine · 2022Article
- Independent effects of adiposity measures on risk of atrial fibrillation in men and women: a study of 0.5 million individuals.International journal of epidemiology · 2022Article
- Healthy US population reference values for CT visceral fat measurements and the impact of IV contrast, HU range, and spinal levels.Scientific reports · 2022Article
- The effect of obesity, hypertension, diabetes mellitus, alcohol, and sleep apnea on the risk of atrial fibrillation.Physiological research · 2021Review
- Crossroads between Estrogen Loss, Obesity, and Heart Failure with Preserved Ejection Fraction.Arquivos brasileiros de cardiologia · 2021Review
- Increased Pericardial Adipose Tissue in Smokers.Journal of clinical medicine · 2021Article
- Accumulation of Pericardial Fat Is Associated With Alterations in Heart Rate Variability Patterns in Hypercholesterolemic Pigs.Circulation. Arrhythmia and electrophysiology · 2020Article
- Obesity-associated alterations in cardiac connexin-43 and PKC signaling are attenuated by melatonin and omega-3 fatty acids in female rats.Molecular and cellular biochemistry · 2019Article
- Association of serum adropin with the presence of atrial fibrillation and atrial remodeling.Journal of clinical laboratory analysis · 2019Article
- Manifestations and mechanisms of myocardial lipotoxicity in obesity.Journal of internal medicine · 2018Review
- Sex differences in pericardial adipose tissue assessed by PET/CT and association with cardiometabolic risk.Acta radiologica (Stockholm, Sweden : 1987) · 2018Article
- Association of serum nesfatin-1 concentrations with atrial fibrillation.The Kaohsiung journal of medical sciences · 2018Article
- Atrial Fibrillation Catheter Ablation: Overcoming Complications and Improving Success.The Journal of innovations in cardiac rhythm management · 2017Review
- Pericardial fat volume and incident atrial fibrillation in the Multi-Ethnic Study of Atherosclerosis and Jackson Heart Study.Obesity (Silver Spring, Md.) · 2017Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
Obesity is associated with increased risk of developing atrial fibrillation (AF). Different fat depots may have differential associations with cardiac pathology. We examined the longitudinal associations between pericardial, intrathoracic, and visceral fat with incident AF. We studied Framingham Heart Study Offspring and Third-Generation Cohorts who participated in the multidetector computed tomography substudy examination 1. We constructed multivariable-adjusted Cox proportional hazard models for risk of incident AF. Body mass index was included in the multivariable-adjusted model as a secondary adjustment. We included 2,135 participants (53.3% women; mean age 58.8 years). During a median follow-up of 9.7 years, we identified 162 cases of incident AF. Across the increasing tertiles of pericardial fat volume, age- and gender-adjusted incident AF rate per 1,000 person-years of follow-up were 8.4, 7.5, and 10.2. Based on an age- and gender-adjusted model, greater pericardial fat (hazard ratio [HR] 1.17, 95% confidence interval [CI] 1.03 to 1.34) and intrathoracic fat (HR 1.24, 95% CI 1.06 to 1.45) were associated with an increased risk of incident AF. The HRs (95% CI) for incident AF were 1.13 (0.99 to 1.30) for pericardial fat, 1.19 (1.01 to 1.40) for intrathoracic fat, and 1.09 (0.93 to 1.28) for abdominal visceral fat after multivariable adjustment. After additional adjustment of body mass index, none of the associations remained significant (all p >0.05). Our findings suggest that cardiac ectopic fat depots may share common risk factors with AF, which may have led to a lack of independence in the association between pericardial fat with incident AF.
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