ArticleThe American journal of cardiology2016
Metabolomic Profiling in Relation to New-Onset Atrial Fibrillation (from the Framingham Heart Study).
Article in The American journal of cardiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Protective effect of uridine on atrial fibrillation: a Mendelian randomisation study.Scientific reports · 2023Pooled it
- Longitudinal Plasma Lipidomic Changes in Chinese Patients with Nonvalvular Atrial Fibrillation During 12 Weeks of Edoxaban Treatment.Metabolites · 2026Article
- Metabolomics Profiling of Epicardial Adipose Tissue: MESA and the Rotterdam Study.Journal of the American Heart Association · 2025Article
- New Onset Atrial Fibrillation in Hospitalized Patients.Journal of community hospital internal medicine perspectives · 2025Article
- Metabolomics in Atrial Fibrillation: Unlocking Novel Biomarkers and Pathways for Diagnosis, Prognosis, and Personalized Treatment.Journal of clinical medicine · 2024Review
- Genetics, transcriptomics, metagenomics, and metabolomics in the pathogenesis and prediction of atrial fibrillation.European heart journal supplements : journal of the European Society of Cardiology · 2024Article
- Metabolomic Profiles, Ideal Cardiovascular Health, and Risk of Heart Failure and Atrial Fibrillation: Insights From the Framingham Heart Study.Journal of the American Heart Association · 2023Article
- Plasma lipidome and risk of atrial fibrillation: results from the PREDIMED trial.Journal of physiology and biochemistry · 2023Article
- The association between eicosanoids and incident atrial fibrillation in the Framingham Heart Study.Scientific reports · 2022Article
- Comprehensive metabolomic characterization of atrial fibrillation.Frontiers in cardiovascular medicine · 2022Article
- New biomarkers from multiomics approaches: improving risk prediction of atrial fibrillation.Cardiovascular research · 2021Review
- Glycolysis Metabolites and Risk of Atrial Fibrillation and Heart Failure in the PREDIMED Trial.Metabolites · 2021Article
- Multicohort Metabolomics Analysis Discloses 9-Decenoylcarnitine to Be Associated With Incident Atrial Fibrillation.Journal of the American Heart Association · 2021Article
- Application of Differential Network Enrichment Analysis for Deciphering Metabolic Alterations.Metabolites · 2020Article
- Altered Acylcarnitine Metabolism Is Associated With an Increased Risk of Atrial Fibrillation.Journal of the American Heart Association · 2020Article
- Association between plasma betaine levels and dysglycemia in patients with coronary artery disease.Bioscience reports · 2020Article
- Comprehensive metabolomic and proteomic analyses reveal candidate biomarkers and related metabolic networks in atrial fibrillation.Metabolomics : Official journal of the Metabolomic Society · 2019Article
- Serum Metabolomics and Incidence of Atrial Fibrillation (from the Atherosclerosis Risk in Communities Study).The American journal of cardiology · 2019Article
- The Biomarkers NT-proBNP and CA-125 are Elevated in Patients with Idiopathic Atrial Fibrillation.Journal of atrial fibrillation · 2018Article
- Combinational Biomarkers for Atrial Fibrillation Derived from Atrial Appendage and Plasma Metabolomics Analysis.Scientific reports · 2018Article
Corrections and comments
- Erratum issued
Authors and funding
16 authors at 7 institutions in 3 countries.
Funding
Abstract
Previous studies have shown several metabolic biomarkers to be associated with prevalent and incident atrial fibrillation (AF), but the results have not been replicated. We investigated metabolite profiles of 2,458 European ancestry participants from the Framingham Heart Study without AF at the index examination and followed them for 10 years for new-onset AF. Amino acids, organic acids, lipids, and other plasma metabolites were profiled by liquid chromatography-tandem mass spectrometry using fasting plasma samples. We conducted Cox proportional hazard analyses for association between metabolites and new-onset AF. We performed hypothesis-generating analysis to identify novel metabolites and hypothesis-testing analysis to confirm the previously reported associations between metabolites and AF. Mean age was 55.1 ± 9.9 years, and 53% were women. Incident AF developed in 156 participants (6.3%) in 10 years of follow-up. A total of 217 metabolites were examined, consisting of 54 positively charged metabolites, 59 negatively charged metabolites, and 104 lipids. None of the 217 metabolites met our a priori specified Bonferroni corrected level of significance in the multivariate analyses. We were unable to replicate previous results demonstrating associations between metabolites that we had measured and AF. In conclusion, in our metabolomics approach, none of the metabolites we tested were significantly associated with the risk of future AF.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.