ArticlePsychosomatics
Agitation, Delirium, and Cognitive Outcomes in Intracerebral Hemorrhage.
Article in Psychosomatics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- The associations of post-stroke delirium with outcomes: a systematic review and meta-analysis.BMC medicine · 2024Pooled it
- Delirium Monitoring in Neurocritically Ill Patients: A Systematic Review.Critical care medicine · 2018Pooled it
- Effect of Neurologic Conditions on Delirium Duration and Time to ICU Discharge.Critical care explorations · 2026Observational
- Survivorship After Neurocritical Care: A Scoping Review of Outcomes Beyond Physical Status.Neurocritical care · 2024Article
- Neurologic Manifestations of Common Variable Immunodeficiency: Impact on Quality of Life.Neurology(R) neuroimmunology & neuroinflammation · 2023Article
- Patient-proxy agreement on change in acute stroke patient-reported outcome measures: a prospective study.Journal of patient-reported outcomes · 2021Article
- Delirium Assessment in Critically Ill Older Adults: Considerations During the COVID-19 Pandemic.Critical care clinics · 2021Review
- Stress-Induced Behavioral Quiescence and Abnormal Rest-Activity Rhythms During Critical Illness.Critical care medicine · 2020Article
- Long-Term Cognitive Impairment Associated With Delirium in Acute Neurological Injury.Critical care explorations · 2020Article
- Why Physicians Prescribe Prophylactic Seizure Medications after Intracerebral Hemorrhage: An Adaptive Conjoint Analysis.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2020Article
- Predisposing and precipitating factors for delirium in neurology: a prospective cohort study of 1487 patients.Journal of neurology · 2019Article
- Review: Post-Intensive Care Syndrome: Unique Challenges in the Neurointensive Care Unit.Neurocritical care · 2019Review
- Article
- Delirium Assessment in Acute Stroke: A Systematic Review and Meta-Analysis of Incidence, Assessment Tools, and Assessment Frequencies.Journal of central nervous system disease · 2019Review
- Prophylactic Seizure Medication and Health-Related Quality of Life After Intracerebral Hemorrhage.Critical care medicine · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
backgroundDelirium predicts higher long-term cognitive morbidity. We previously identified a cohort of patients with spontaneous intracerebral hemorrhage and delirium and found worse outcomes in health-related quality of life (HRQoL) in the domain of cognitive function.
objectiveWe tested the hypothesis that agitation would have additional prognostic significance on later cognitive function HRQoL.
methodsProspective identification of 174 patients with acute intracerebral hemorrhage, measuring stroke severity, agitation, and delirium, with a standardized protocol and measures. HRQoL was assessed using the Neuro-QOL at 28 days, 3 months, and 1 year. Functional outcomes were measured with the modified Rankin Scale.
resultsAmong the 81 patients with HRQoL follow-up data available, patients who had agitation and delirium had worse cognitive function HRQoL scores at 28 days (T scores for delirium with agitation 20.9 ± 7.3, delirium without agitation 30.4 ± 16.5, agitation without delirium 36.6 ± 17.5, and neither agitated nor delirious 40.3 ± 15.9; p = 0.03) and at 1 year (p = 0.006). The effect persisted in mixed models after correction for severity of neurologic injury, age, and time of assessment (p = 0.0006) and was not associated with medication use, seizures, or infection.
conclusionsThe presence of agitation with delirium in patients with intracerebral hemorrhage may predict higher risk of unfavorable cognitive outcomes up to 1 year later.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.