Evidence map›Paper›PMID 27665547›Full record

ArticleJournal of neural transmission (Vienna, Austria : 1996)2016

Neuroprotective effects of various doses of topiramate against methylphenidate-induced oxidative stress and inflammation in isolated rat amygdala: the possible role of CREB/BDNF signaling pathway.

Majid Motaghinejad, Manijeh Motevalian, Reza Falak, Mansour Heidari, Mahshid Sharzad, Elham Kalantari

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of neural transmission (Vienna, Austria : 1996), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 48 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Links between COVID-19 and Alzheimer's Disease-What Do We Already Know?International journal of environmental research and public health · 2023
    Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Majid MotaghinejadRazi Drug Research Center and Department of Pharmacology, School of Medicine, Iran University of Medical Sciences, Hemmat High Way, Beside Milad Tower, 14496-14525, Tehran, Iran.
Manijeh MotevalianRazi Drug Research Center and Department of Pharmacology, School of Medicine, Iran University of Medical Sciences, Hemmat High Way, Beside Milad Tower, 14496-14525, Tehran, Iran. motevalian.m@iums.ac.ir.
Reza FalakDepartment of Immunology, School of Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran.
Mansour HeidariDepartment of Medical Genetics, Tehran University of Medical Sciences, Tehran, Iran.
Mahshid SharzadDepartment of Medical Genetics, Tehran University of Medical Sciences, Tehran, Iran.
Elham KalantariOncopathology Research Center and Department of Pathology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Iran University of Medical Sciences · IRTehran University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Methylphenidate (MPH) abuse damages brain cells. The neuroprotective effects of topiramate (TPM) have been reported previously, but its exact mechanism of action still remains unclear. This study investigated the in vivo role of various doses of TPM in the protection of rat amygdala cells against methylphenidate-induced oxidative stress and inflammation. Seventy adult male rats were divided into seven groups. Groups 1 and 2 received normal saline (0.7 ml/rat) and MPH (10 mg/kg), respectively, for 21 days. Groups 3, 4, 5, 6, and 7 were concurrently treated with MPH (10 mg/kg) and TPM (10, 30, 50, 70, and 100 mg/kg), respectively, for 21 days. elevated plus maze (EPM) was used to assess motor activity disturbances. In addition, oxidative, antioxidantand inflammatory factors and CREB, Ak1, CAMK4, MAPK3, PKA, BDNF, and c FOS gene levels were measured by RT-PCR, and also, CREB and BDNF protein levels were measured by WB in isolated amygdalae. MPH significantly disturbed motor activity and TPM (70 and 100 mg/kg) neutralized its effects. MPH significantly increased lipid peroxidation, mitochondrial GSSG levels and IL-1β and TNF-α level and CAMK4 gene expression in isolated amygdala cells. In contrast, superoxide dismutase, glutathione peroxidase, and glutathione reductase activities and CREB, BDNF Ak1, MAPK3, PKA, BDNF, and c FOS expression significantly decreased. The various doses of TPM attenuated these effects of MPH. It seems that TPM can be used as a neuroprotective agent and is a good candidate against MPH-induced neurodegeneration.

Indexed as

AnimalsBrain-Derived Neurotrophic FactorCentral Nervous System StimulantsCREB-Binding ProteinDisease Models, AnimalDose-Response Relationship, DrugEncephalitisFructoseGlutathioneGlutathione PeroxidaseGlutathione ReductaseLipid PeroxidationMaleMaze LearningMethylphenidateMitochondriaBrain-Derived Neurotrophic FactorCentral Nervous System StimulantsCREB-Binding ProteinFructoseGlutathioneGlutathione PeroxidaseGlutathione ReductaseMethylphenidateNeuroprotective AgentsSuperoxide DismutaseTopiramateAmygdalaBDNFInflammationMethylphenidateOxidative stressTopiramate

Identifiers

PMID27665547
OpenAlexW2521839510

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.