Evidence map›Paper›PMID 27665369›Full record

ArticleThe American journal of pathology2016

Fibromodulin Is Essential for Fetal-Type Scarless Cutaneous Wound Healing.

Zhong Zheng, Xinli Zhang, Catherine Dang, Steven Beanes, Grace X Chang, Yao Chen, Chen-Shuang Li, Kevin S Lee, Kang Ting, Chia Soo

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of pathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 56 citations in OpenAlex.

  1. Review
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  10. Mesodermal Derivatives of Pluripotent Stem Cells Route to Scarless Healing.International journal of molecular sciences · 2023
    Review
  11. Review
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Healing Mechanisms in Cutaneous Wounds: Tipping the Balance.Tissue engineering. Part B, Reviews · 2022
    Review
  18. Review
  19. Gene Expression Profiling of Monozygotic Twins Affected by Psoriatic Arthritis.Open access rheumatology : research and reviews · 2021
    Article
  20. BioflavonoidEvidence-based complementary and alternative medicine : eCAM · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Zhong ZhengDental and Craniofacial Research Institute and Section of Orthodontics, School of Dentistry, University of California, Los Angeles, Los Angeles, California; UCLA Division of Plastic and Reconstructive Surgery, the Department of Orthopaedic Surgery, and the Orthopaedic Hospital Research Center, University of California, Los Angeles, Los Angeles, California.
Xinli ZhangDental and Craniofacial Research Institute and Section of Orthodontics, School of Dentistry, University of California, Los Angeles, Los Angeles, California.
Catherine DangSaul & Joyce Brandman Breast Center, Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, California.
Steven BeanesHoag Hospital, Newport Beach, California.
Grace X ChangDepartment of Surgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California.
Yao ChenDental and Craniofacial Research Institute and Section of Orthodontics, School of Dentistry, University of California, Los Angeles, Los Angeles, California.
Chen-Shuang LiDental and Craniofacial Research Institute and Section of Orthodontics, School of Dentistry, University of California, Los Angeles, Los Angeles, California.
Kevin S LeeDental and Craniofacial Research Institute and Section of Orthodontics, School of Dentistry, University of California, Los Angeles, Los Angeles, California.
Kang TingDental and Craniofacial Research Institute and Section of Orthodontics, School of Dentistry, University of California, Los Angeles, Los Angeles, California; UCLA Division of Plastic and Reconstructive Surgery, the Department of Orthopaedic Surgery, and the Orthopaedic Hospital Research Center, University of California, Los Angeles, Los Angeles, California; Department of Bioengineering, School of Engineering, University of California, Los Angeles, Los Angeles, California. Electronic address: kting@dentistry.ucla.edu.
Chia SooUCLA Division of Plastic and Reconstructive Surgery, the Department of Orthopaedic Surgery, and the Orthopaedic Hospital Research Center, University of California, Los Angeles, Los Angeles, California. Electronic address: bsoo@ucla.edu.
University of California, Los Angeles · USCedars-Sinai Medical Center · USHoag Memorial Hospital Presbyterian · US

Funding

Novel peptide-impregnated hydrogel as a wound healing deviceR44DE026080 · NIDCR · SCARLESS LABORATORIES, INC. · PI SOO, CHIA, ZHENG, ZHONG · 2016 to 2023
$4.7M
Anti-scar peptide for cleft lip repairR44DE024692 · NIDCR · SCARLESS LABORATORIES, INC. · PI SOO, CHIA, ZHENG, ZHONG · 2014 to 2016
$1.5M
A novel anti-scar peptide for cutaneous wound repairR44AR064126 · NIAMS · SCARLESS LABORATORIES, INC. · PI SOO, CHIA, ZHENG, ZHONG · 2015 to 2016
$1.5M
A novel anti-scar peptide for cutaneous wound repairR43AR064126 · NIAMS · SCARLESS LABORATORIES, INC. · PI PANG, SHEN, SOO, CHIA · 2013 to 2014
$398k
Safety and efficacy testing of novel anti-scar peptide vs corticosteroid for scarR43AR063558 · NIAMS · SCARLESS LABORATORIES, INC. · PI PANG, SHEN, SOO, CHIA · 2014 to 2015
$397k
NIAMS NIH HHS R43 AR063558NIAMS NIH HHS R43 AR064126NIAMS NIH HHS R44 AR064126NIDCR NIH HHS R44 DE024692NIDCR NIH HHS R44 DE026080
6 · The paper itself

Abstract

In contrast to adult and late-gestation fetal skin wounds, which heal with scar, early-gestation fetal skin wounds display a remarkable capacity to heal scarlessly. Although the underlying mechanism of this transition from fetal-type scarless healing to adult-type healing with scar has been actively investigated for decades, in utero restoration of scarless healing in late-gestation fetal wounds has not been reported. In this study, using loss- and gain-of-function rodent fetal wound models, we identified that fibromodulin (Fm) is essential for fetal-type scarless wound healing. In particular, we found that loss of Fm can eliminate the ability of early-gestation fetal rodents to heal without scar. Meanwhile, administration of fibromodulin protein (FM) alone was capable of restoring scarless healing in late-gestation rat fetal wounds, which naturally heal with scar, as characterized by dermal appendage restoration and organized collagen architectures that were virtually indistinguishable from those in age-matched unwounded skin. High Fm levels correlated with decreased transforming growth factor (TGF)-β1 expression and scarless repair, while low Fm levels correlated with increased TGF-β1 expression and scar formation. This study represents the first successful in utero attempt to induce scarless repair in late-gestation fetal wounds by using a single protein, Fm, and highlights the crucial role that the FM-TGF-β1 nexus plays in fetal-type scarless skin repair.

Indexed as

Gene Expression RegulationWound HealingAnimalsCicatrixCollagenFemaleFetusFibromodulinGene Expression ProfilingGestational AgeMaleMiceOligonucleotide Array Sequence AnalysisRatsRats, Sprague-DawleySkinCollagenFibromodulinTransforming Growth Factor beta1

Identifiers

PMID27665369
PMCPMC5222972
OpenAlexW2522580299

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.