Evidence map›Paper›PMID 27665354›Full record

ArticleVaccine2016

Recovery of antigen-specific T cell responses from dogs infected with Leishmania (L.) infantum by use of vaccine associated TLR-agonist adjuvant.

Robert G Schaut, Tara L Grinnage-Pulley, Kevin J Esch, Angela J Toepp, Malcolm S Duthie, Randall F Howard, Steven G Reed, Christine A Petersen

Abstract read
In one paragraph

Article in Vaccine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Tick-borne coinfections modulate CD8Infection and immunity · 2025
    Article
  3. Article
  4. Article
  5. Enhancing Control ofAnimals : an open access journal from MDPI · 2024
    Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Prevalence of antinuclear antibodies and rheumatoid factor titers in dogs with arthritis secondary to leishmaniosis (Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2022
    Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. The balancing act: Immunology of leishmaniosis.Research in veterinary science · 2020
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Safety Analysis ofThe American journal of tropical medicine and hygiene · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Robert G SchautDepartment of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA 52242, USA; Center for Emerging Infectious Diseases, University of Iowa Research Park, Coralville, IA 52241, USA.
Tara L Grinnage-PulleyDepartment of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA 52242, USA.
Kevin J EschDepartment of Veterinary Pathology, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USA.
Angela J ToeppDepartment of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA 52242, USA; Center for Emerging Infectious Diseases, University of Iowa Research Park, Coralville, IA 52241, USA.
Malcolm S DuthieInfectious Disease Research Institute, Seattle, WA 98102, USA.
Randall F HowardInfectious Disease Research Institute, Seattle, WA 98102, USA.
Steven G ReedInfectious Disease Research Institute, Seattle, WA 98102, USA.
Christine A PetersenDepartment of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA 52242, USA; Center for Emerging Infectious Diseases, University of Iowa Research Park, Coralville, IA 52241, USA. Electronic address: christine-petersen@uiowa.edu.
University of Iowa · USInfectious Disease Research Institute · USIowa State University · US

Funding

Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Douglas Robert Spitz · 2000 to 2026
$70.0M
TRAINING IN MECHANISMS OF PARASITISMT32AI007511 · NIAID · UNIVERSITY OF IOWA · PI BUTLER, NOAH SULLIVAN, WEBER, MARY · 1996 to 2025
$8.1M
LEISHMANIA ANTIGENS DEFINES BY IMMUNE RESPONSESR01AI025038 · NIAID · SEATTLE BIOMEDICAL RESEARCH INSTITUTE · PI REED, STEVEN GREGORY · 1987 to 2016
$5.6M
NIAID NIH HHS R01 AI025038NIAID NIH HHS T32 AI007511
6 · The paper itself

Abstract

Visceral leishmaniasis (VL), caused by infection with the obligate intracellular protozoan parasite Leishmania infantum, is a fatal disease of dogs and humans. Protection against VL requires a T helper 1 (Th1) skewed CD4

Indexed as

Adjuvants, ImmunologicAnimalsAntibodies, ProtozoanAntigens, ProtozoanAsymptomatic DiseasesCD4-Positive T-LymphocytesCytokinesDog DiseasesDogsInterferon-gammaInterleukin-10Leishmania infantumLeishmaniasis, VisceralProtozoan VaccinesToll-Like ReceptorsAdjuvants, ImmunologicAntibodies, ProtozoanAntigens, ProtozoanCytokinesInterferon-gammaInterleukin-10Protozoan VaccinesToll-Like ReceptorsAdjuvantsCD4(+) T cellsCytokinesLeishmania (L.) infantumToll-like receptor agonist

Identifiers

PMID27665354
PMCPMC5053902
OpenAlexW2522474051

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.