ArticleJournal of cellular and molecular medicine2017
Peripheral nerve injury induces adult brain neurogenesis and remodelling.
Article in Journal of cellular and molecular medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 34 citations in OpenAlex.
- Article
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- Re-examining the Mysterious Role of the Cerebellum in Pain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- Neural regeneration therapy after spinal cord injury induces unique brain functional reorganizations in rhesus monkeys.Annals of medicine · 2022Article
- Effect of gabapentin on neurogenesis in hippocampal dentate gyrus of adult rats with co-disease of chronic pain and depression.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2022Article
- Neuroinflammation Mediates Faster Brachial Plexus Regeneration in Subjects with Cerebral Injury.Neuroscience bulletin · 2021Article
- 3D microelectrode cluster and stimulation paradigm yield powerful analgesia without noticeable adverse effects.Science advances · 2021Article
- Self-Assembling Hydrogel Structures for Neural Tissue Repair.ACS biomaterials science & engineering · 2021Review
- Adeno-Associated Virus-Mediated Gene Therapy in the Mashlool,Human gene therapy · 2021Article
- Microglia: sculptors of neuropathic pain?Royal Society open science · 2020Review
- Acupuncture-Analgesia-Mediated Alleviation of Central Sensitization.Evidence-based complementary and alternative medicine : eCAM · 2019Review
- Article
- Impact of neonatal hypoxia-ischaemia on oligodendrocyte survival, maturation and myelinating potential.Journal of cellular and molecular medicine · 2018Article
- Down-Regulated Drebrin Aggravates Cognitive Impairments in a Mouse Model of Alzheimer's Disease.International journal of molecular sciences · 2017Article
- Reduced GABAergic neuronal activity in zona incerta causes neuropathic pain in a rat sciatic nerve chronic constriction injury model.Journal of pain research · 2017Article
- Adult spinal cord neurogenesis: A regulator of nociception.Neurogenesis (Austin, Tex.) · 2016Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Unilateral peripheral nerve chronic constriction injury (CCI) has been widely used as a research model of human neuropathic pain. Recently, CCI has been shown to induce spinal cord adult neurogenesis, which may contribute to the chronic increase in nociceptive sensitivity. Here, we show that CCI also induces rapid and profound asymmetrical anatomical rearrangements in the adult rodent cerebellum and pons. This remodelling occurs throughout the hindbrain, and in addition to regions involved in pain processing, also affects other sensory modalities. We demonstrate that these anatomical changes, partially reversible in the long term, result from adult neurogenesis. Neurogenic markers Mash1, Ngn2, doublecortin and Notch3 are widely expressed in the rodent cerebellum and pons, both under normal and injured conditions. CCI-induced hindbrain structural plasticity is absent in Notch3 knockout mice, a strain with impaired neuronal differentiation, demonstrating its dependence on adult neurogenesis. Grey matter and white matter structural changes in human brain, as a result of pain, injury or learned behaviours have been previously detected using non-invasive neuroimaging techniques. Because neurogenesis-mediated structural plasticity is thought to be restricted to the hippocampus and the subventricular zone, such anatomical rearrangements in other parts of the brain have been thought to result from neuronal plasticity or glial hypertrophy. Our findings suggest the presence of extensive neurogenesis-based structural plasticity in the adult mammalian brain, which may maintain a memory of basal sensory levels, and act as an adaptive mechanism to changes in sensory inputs.
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