ArticleSchizophrenia research2017
Cortical thickness of neural substrates supporting cognitive empathy in individuals with schizophrenia.
Article in Schizophrenia research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Meta-analysis of cortical thickness reduction in adult schizophrenia.Journal of psychiatry & neuroscience : JPNPooled it
- Predicting the degree of trait emotional empathy from cortical features using surface-based morphometry.Scientific reports · 2026Article
- Frontotemporal cortical thinning and insular surface area reduction in schizophrenia with predominant negative symptoms.BMC psychiatry · 2026Article
- Narcissistic and Antisocial Personality Traits Are Both Encoded in the Triple Network: Connectomics Evidence.Psychophysiology · 2025Article
- Childhood abuse and neglect are differentially related to perceived discrimination and structural change in empathy-related circuitry.Scientific reports · 2025Article
- Clinical anatomy of the precuneus and pathogenesis of the schizophrenia.Anatomical science international · 2023Review
- The role of the insula in cognitive impairment of schizophrenia.Schizophrenia research. Cognition · 2023Review
- Neurocircuitry of Personality Traits and Intent in Decision-Making.Behavioral sciences (Basel, Switzerland) · 2023Review
- Cognitive Stress Regulation in Schizophrenia Patients and Healthy Individuals: Brain and Behavior.Journal of clinical medicine · 2023Article
- Probing the role of the right inferior frontal gyrus during Pain-Related empathy processing: Evidence from fMRI and TMS.Human brain mapping · 2021Article
- Cognitive Empathy and Longitudinal Changes in Temporo-Parietal Junction Thickness in Schizophrenia.Frontiers in psychiatry · 2021Article
- Psychometric Properties of Questionnaire of Cognitive and Affective Empathy (QCAE): Reliability and Factor Analysis Study in Turkish Sample.Noro psikiyatri arsivi · 2021Article
- Effect of Risperidone Monotherapy on Dynamic Functional Connectivity of Insular Subdivisions in Treatment-Naive, First-Episode Schizophrenia.Schizophrenia bulletin · 2020Article
- The role of the inferior frontal gyrus in vicarious social touch: A transcranial direct current stimulation (tDCS) study.Developmental cognitive neuroscience · 2019Article
- Neuroanatomical and Functional Correlates of Cognitive and Affective Empathy in Young Healthy Adults.Frontiers in behavioral neuroscience · 2019Article
- The Effect of High-Definition Transcranial Direct Current Stimulation of the Right Inferior Frontal Gyrus on Empathy in Healthy Individuals.Frontiers in human neuroscience · 2018Article
- Psychometric properties of the questionnaire of cognitive and affective empathy in a Portuguese sample.PloS one · 2018Article
- Cortical thickness and trait empathy in patients and people at high risk for alcohol use disorders.Psychopharmacology · 2017Article
- Multimodal Discrimination of Schizophrenia Using Hybrid Weighted Feature Concatenation of Brain Functional Connectivity and Anatomical Features with an Extreme Learning Machine.Frontiers in neuroinformatics · 2017Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundCognitive empathy is supported by the medial prefrontal cortex (mPFC), inferior frontal gyrus (IFG), anterior mid-cingulate cortex (aMCC), insula (INS), supplementary motor area (SMA), right temporo-parietal junction (TPJ), and precuneus (PREC). In healthy controls, cortical thickness in these regions has been linked to cognitive empathy. As cognitive empathy is impaired in schizophrenia, we examined whether reduced cortical thickness in these regions was associated with poorer cognitive empathy in this population.
methods41 clinically-stable community-dwelling individuals with schizophrenia and 46 healthy controls group-matched on demographic variables completed self-report empathy questionnaires, a cognitive empathy task, and structural magnetic resonance imaging. We examined between-group differences in study variables using t-tests and analyses of variance. Next, we used Pearson correlations to evaluate the relationship between cognitive empathy and cortical thickness in the mPFC, IFG, aMCC, INS, SMA, TPJ, and PREC in both groups.
resultsIndividuals with schizophrenia demonstrated cortical thinning in the IFG, INS, SMA, TPJ, and PREC (all p<0.05) and impaired cognitive empathy across all measures (all p<0.01) relative to controls. While cortical thickness in the mPFC, IFC, aMCC, and INS (all p<0.05) was related to cognitive empathy in controls, we did not observe these relationships in individuals with schizophrenia (all p>0.10).
conclusionsIndividuals with schizophrenia have reduced cortical thickness in empathy-related neural regions and significant impairments in cognitive empathy. Interestingly, cortical thickness was related to cognitive empathy in controls but not in the schizophrenia group. We discuss other mechanisms that may account for cognitive empathy impairment in schizophrenia.
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