Evidence map›Paper›PMID 27665063›Full record

ReviewTrends in cell biology2017

Hitchhiking: A Non-Canonical Mode of Microtubule-Based Transport.

John Salogiannis, Samara L Reck-Peterson

Abstract readReview
In one paragraph

Review in Trends in cell biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Deciphering the RNA-binding protein network during endosomal mRNA transport.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. The structural properties of full-length annexin A11.Frontiers in molecular biosciences · 2024
    Article
  11. Article
  12. Article
  13. Article
  14. Heme sensing and trafficking in fungi.Fungal biology reviews · 2023
    Article
  15. Article
  16. Article
  17. Review
  18. Kinesin Motors in the Filamentous Basidiomycetes in Light of theJournal of fungi (Basel, Switzerland) · 2022
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

John SalogiannisDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093, USA; Section of Cell and Developmental Biology, Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
Samara L Reck-PetersonDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093, USA; Section of Cell and Developmental Biology, Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: sreckpeterson@ucsd.edu.

Funding

Regulation of Cytoplasmic DyneinR01GM107214 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LESCHZINER, ANDRES · 2014 to 2021
$3.1M
Cellular control of microtubule-based transport.R01GM121772 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI RECK-PETERSON, SAMARA L · 2017 to 2020
$1.6M
Dissecting dynein motor function using DNA nanotechnologyR01GM100947 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI RECK-PETERSON, SAMARA L · 2013 to 2016
$1.2M
NIGMS NIH HHS R01 GM100947NIGMS NIH HHS R01 GM107214NIGMS NIH HHS R01 GM121772
6 · The paper itself

Abstract

The long-range movement of organelles, vesicles, and macromolecular complexes by microtubule-based transport is crucial for cell growth and survival. The canonical view of intracellular transport is that each cargo directly recruits molecular motors via cargo-specific adaptor molecules. Recently, a new paradigm called 'hitchhiking' has emerged: some cargos can achieve motility by interacting with other cargos that have already recruited molecular motors. In this way, cargos are co-transported together and their movements are directly coupled. Cargo hitchhiking was discovered in fungi. However, the observation that organelle dynamics are coupled in mammalian cells suggests that this paradigm may be evolutionarily conserved. We review here the data for hitchhiking and discuss the biological significance of this non-canonical mode of microtubule-based transport.

Indexed as

AnimalsBiological TransportEndosomesHumansMammalsMicrotubulesModels, BiologicalRNA, MessengerRNA, Messengerdyneinendosomehitchhikingkinesinmicrotubuleperoxisome

Identifiers

PMID27665063
PMCPMC5258766

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.