Trial reportSchizophrenia bulletin2017
Housing First Improves Adherence to Antipsychotic Medication Among Formerly Homeless Adults With Schizophrenia: Results of a Randomized Controlled Trial.
Trial report in Schizophrenia bulletin, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- A systematic review of approaches to improve medication adherence in homeless adults with psychiatric disorders.Frontiers in psychiatry · 2023Pooled it
- Psychosocial interventions for people with both severe mental illness and substance misuse.The Cochrane database of systematic reviews · 2019Pooled it
- Homeless women with schizophrenia reported lower adherence to their medication than men: results from the French Housing First experience.Social psychiatry and psychiatric epidemiology · 2017Trial
- Assertive Community Treatment and ACT-Derived Outreach Models: A Scoping Review of Adaptations, Fidelity and Outcomes.Community mental health journal · 2026Article
- Psychosocial Management of First-Episode Psychosis and Schizophrenia: Synopsis of the US Department of Veterans Affairs and US Department of Defense Clinical Practice Guidelines.Schizophrenia bulletin · 2025Article
- High support housing for people with serious mental illness in Canada: a scoping review.Frontiers in psychiatry · 2025Review
- [Association Between Medication Compliance and Various Risky Behaviors in Patients With Schizophrenia].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2023Article
- Exploring the effect of case management in homelessness per components: A systematic review of effectiveness and implementation, with meta-analysis and thematic synthesis.Campbell systematic reviews · 2023Review
- Medication Nonadherence and Risk of Violence to Others Among Patients With Schizophrenia in Western China.JAMA network open · 2023Article
- Article
- Accommodation-based interventions for individuals experiencing, or at risk of experiencing, homelessness.Campbell systematic reviews · 2021Review
- A comprehensive review of prioritised interventions to improve the health and wellbeing of persons with lived experience of homelessness.Campbell systematic reviews · 2021Review
- Homelessness as a predictor of mortality: an 11-year register-based cohort study.Social psychiatry and psychiatric epidemiology · 2018Article
- Characteristics of adherence to methadone maintenance treatment over a 15-year period among homeless adults experiencing mental illness.Addictive behaviors reports · 2017Article
- Adherence to Antipsychotic Medication and Criminal Recidivism in a Canadian Provincial Offender Population.Schizophrenia bulletin · 2017Article
- Interventions to mitigate the effects of poverty and inequality on mental health.Social psychiatry and psychiatric epidemiology · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Adherence to antipsychotic medication is a significant challenge among homeless patients. No experimental trials have investigated the impact of Housing First on adherence among patients with schizophrenia. We investigated whether Housing First in congregate and scattered-site configurations resulted in superior adherence compared to usual care. Adult participants (n = 165) met criteria for homelessness, schizophrenia, and initiation of antipsychotic pharmacotherapy prior to recruitment to an unblinded, 3-arm randomized controlled trial in Vancouver, Canada. Randomization arms were: congregate Housing First (CHF) with on-site supports (including physician and pharmacy services); scattered-site Housing First (SHF) with Assertive Community Treatment; or treatment as usual (TAU) consisting of existing services. Participants were followed for an average of 2.6 years. Adherence to antipsychotic medication was measured using the medication possession ratio (MPR), and 1-way ANOVA was used to compare outcomes between the 3 conditions. Data were drawn from comprehensive pharmacy records. Prior to randomization, mean MPR among participants was very low (0.44-0.48). Mean MPR in the follow-up period was significantly different between study arms (P < .001) and approached the guideline threshold of 0.80 in SHF. Compared to TAU, antipsychotic adherence was significantly higher in SHF but not in CHF. The results demonstrate that further implementation of SHF is indicated among homeless people with schizophrenia, and that urgent action is needed to address very low levels of antipsychotic adherence in this population (trial registration: ISRCTN57595077).
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.