ArticleCerebral cortex (New York, N.Y. : 1991)2016
Distinct Corticostriatal and Intracortical Pathways Mediate Bilateral Sensory Responses in the Striatum.
Article in Cerebral cortex (New York, N.Y. : 1991), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Somatosensory cortex shapes perceptual decision bias via the superior colliculus.Research square · 2026Article
- Prefrontal modulation of striatal engagement: a hierarchical framework for goal-directed behavior.Communications biology · 2026Review
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- Article
- Formation of an auditory sensory representation in posterior striatum emerges during a brief temporal window of associative learning in normal and hearing-impaired gerbils.Frontiers in systems neuroscience · 2025Article
- Article
- Symmetry in Frontal But Not Motor and Somatosensory Cortical Projections.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Symmetry in frontal but not motor and somatosensory cortical projections.bioRxiv : the preprint server for biology · 2024Article
- The Interactions of Temporal and Sensory Representations in the Basal Ganglia.Advances in experimental medicine and biology · 2024Review
- Callosal inputs generate side-invariant receptive fields in the barrel cortex.Science advances · 2023Article
- Motor cortex gates distractor stimulus encoding in sensory cortex.Nature communications · 2023Article
- Dorsolateral Striatum is a Bottleneck for Responding to Task-Relevant Stimuli in a Learned Whisker Detection Task in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Ongoing movement controls sensory integration in the dorsolateral striatum.Nature communications · 2023Article
- Striatal Dopamine Signals and Reward Learning.Function (Oxford, England) · 2023Review
- Reduction of corpus callosum activity during whisking leads to interhemispheric decorrelation.Nature communications · 2021Article
- Medium spiny neurons activity reveals the discrete segregation of mouse dorsal striatum.eLife · 2021Article
- Cell Type-Specific Membrane Potential Changes in Dorsolateral Striatum Accompanying Reward-Based Sensorimotor Learning.Function (Oxford, England) · 2021Article
- Intrinsic electrophysiological properties predict variability in morphology and connectivity among striatal Parvalbumin-expressing Pthlh-cells.Scientific reports · 2020Article
- The Functional Organization of Cortical and Thalamic Inputs onto Five Types of Striatal Neurons Is Determined by Source and Target Cell Identities.Cell reports · 2020Article
- Converging sensory and motor cortical inputs onto the same striatal neurons: An in vivo intracellular investigation.PloS one · 2020Article
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Authors and funding
2 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Individual striatal neurons integrate somatosensory information from both sides of the body, however, the afferent pathways mediating these bilateral responses are unclear. Whereas ipsilateral corticostriatal projections are prevalent throughout the neocortex, contralateral projections provide sparse input from primary sensory cortices, in contrast to the dense innervation from motor and frontal regions. There is, therefore, an apparent discrepancy between the observed anatomical pathways and the recorded striatal responses. We used simultaneous in vivo whole-cell and extracellular recordings combined with focal cortical silencing, to dissect the afferent pathways underlying bilateral sensory integration in the mouse striatum. We show that unlike direct corticostriatal projections mediating responses to contralateral whisker deflection, responses to ipsilateral stimuli are mediated mainly by intracortical projections from the contralateral somatosensory cortex (S1). The dominant pathway is the callosal projection from contralateral to ipsilateral S1. Our results suggest a functional difference between the cortico-basal ganglia pathways underlying bilateral sensory and motor processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.