ArticleAnnals of epidemiology2016
Birth weight was longitudinally associated with cardiometabolic risk markers in mid-adulthood.
Article in Annals of epidemiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00005129 (The Bogalusa Heart Study), which is not on this map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Bogalusa Heart Study
Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Atypical forms of diabetes mellitus in Africans and other non-European ethnic populations in low- and middle-income countries: a systematic literature review.Journal of global health · 2019Pooled it
- The Influence of the Sympathetic Nervous System on Cardiometabolic Health in Response to Weight Gain or Weight Loss.Metabolites · 2025Review
- Association of size for gestational age and dehydroepiandrosterone sulfate with cardiometabolic risk in central precocious puberty girls.Frontiers in endocrinology · 2023Article
- Birth size, growth trajectory and later cardio-metabolic risk.Frontiers in endocrinology · 2023Review
- Gestational weight gain mediates the effects of energy intake on birth weight among singleton pregnancies in the Japan Environment and Children's Study.BMC pregnancy and childbirth · 2022Article
- Birth Weight and Maternal Body Size as Determinants of Blood Pressure at Age 17: Results from the Jerusalem Perinatal Study Cohort.Maternal and child health journal · 2021Article
- Birthweight correlates with later metabolic abnormalities in Chinese patients with maturity-onset diabetes of the young type 2.Endocrine · 2019Article
- Birthweight and cardiometabolic risk patterns in multiracial children.International journal of obesity (2005) · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
purposeBirth weight (BW) is associated with risk of cardiovascular (CV) disease. The findings from studies examined the association of BW with metabolic markers of CV risk were inconsistent and controversial. We examined the association of BW with insulin resistance and blood lipids using repeated measures up to mid-adulthood.
methodsData from seven screenings of the Bogalusa Heart Study-a longitudinal study of cardiovascular risk factors in Bogalusa, LA-are analyzed using generalized estimation equations method. Participants with birth data and at least one measurement of study outcomes between 18 and 44 years (n = 2,034) were included.
resultsBW is inversely associated with insulin resistance, triglycerides, and total cholesterol (P < .01 for all). For 1-kg decrease in BW, insulin resistance increased by 2.3 units, 95% confidence interval (CI) = 0.7-3.9; triglycerides by 8.7 mg per dL, 95% CI = 4.9-12.4, and total cholesterol by 5.4 mg per dL, 95% CI = 1.8-9.1. The association of body mass with adult blood lipids levels is weaker in persons with low versus normal BW.
conclusionsThe study provides strong evidence of an inverse relationship of BW with adulthood cardiometabolic risk profile. Persons born with low BW are maybe less responsive to preventive interventions aiming at weight reduction.
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Registered trials
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