ArticleDomestic animal endocrinology2017
A miRNA target network putatively involved in follicular atresia.
Article in Domestic animal endocrinology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 49 citations in OpenAlex.
- Alternations in the expression of hypoxia inducible factor 1 alpha (HIF1α) and selected angiogenesis-related genes in the hen ovary in relation to follicle development and atresia.Poultry science · 2026Article
- Premature ovarian insufficiency restoration after chemotherapy: current achievements and future prospects on its treatment or management.Journal of ovarian research · 2025Review
- Hsa-miR-21-5p and Hsa-miR-145-5p Expression: From Normal Tissue to Malignant Changes-Context-Dependent Correlation with Estrogen- and Hypoxia-Vascularization-Related Pathways Genes: A Pilot Study.International journal of molecular sciences · 2025Article
- miR-383 regulates sheep granular cell proliferation and apoptosis by targetingArchives animal breeding · 2025Article
- A glance into the roles of microRNAs (exosomal and non-exosomal) in polycystic ovary syndrome.Obstetrics & gynecology science · 2024Article
- MicroRNAs in POI, DOR and POR.Archives of gynecology and obstetrics · 2023Review
- Identification of microRNAs implicated in modulating resveratrol-induced apoptosis in porcine granulosa cells.Frontiers in cell and developmental biology · 2023Article
- Comparative miRNA expression profile analysis of porcine ovarian follicles: new insights into the initiation mechanism of follicular atresia.Frontiers in genetics · 2023Article
- Integrated analysis of expression profiles with meat quality traits in cattle.Scientific reports · 2022Article
- Epigenetic regulation in premature ovarian failure: A literature review.Frontiers in physiology · 2022Review
- Death Processes in Bovine Theca and Granulosa Cells Modelled and Analysed Using a Systems Biology Approach.International journal of molecular sciences · 2021Article
- Ovarian Aging: Role of Pituitary-Ovarian Axis Hormones and ncRNAs in Regulating Ovarian Mitochondrial Activity.Frontiers in endocrinology · 2021Review
- Urinary Cell-Free miR-99a-5p as a Potential Biomarker for Estrus Detection in Buffalo.Frontiers in veterinary science · 2021Article
- Transcriptome Analysis of the Chicken Follicular Theca Cells with miR-135a-5p Suppressed.G3 (Bethesda, Md.) · 2020Article
- MicroRNAs regulate granulosa cells apoptosis and follicular development - A review.Asian-Australasian journal of animal sciences · 2020Article
- Article
- Serum microRNA profiling for the identification of predictive molecular markers of the response to controlled ovarian stimulation.JBRA assisted reproduction · 2020Article
- miR-21 and Pellino-1 Expression Profiling in Autoimmune Premature Ovarian Insufficiency.Journal of immunology research · 2020Article
- Variants inAnimals : an open access journal from MDPI · 2019Article
- Roles of microRNAs in mammalian reproduction: from the commitment of germ cells to peri-implantation embryos.Biological reviews of the Cambridge Philosophical Society · 2019Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
In a previous microarray study, we identified a subset of micro RNAS (miRNAs), which expression was distinctly higher in atretic than healthy follicles of cattle. In the present study, we investigated the involvement of those miRNAs in granulosa and theca cells during atresia. Reverse Transcription-quantitative Polymerase Chain Reaction (RT-qPCR) confirmed that miR-21-5p/-3p, miR-150, miR-409a, miR-142-5p, miR-378, miR-222, miR-155, and miR-199a-5p were expressed at higher levels in atretic than healthy follicles (9-17 mm, classified based on steroidogenic capacity). All miRNAs except miR-21-3p and miR-378 were expressed at higher levels in theca than granulosa cells. The expression of 13 predicted miRNA targets was determined in follicular cells by RT-qPCR, revealing downregulation of HIF1A, ETS1, JAG1, VEGFA, and MSH2 in either or both cell types during atresia. Based on increases in miRNA levels simultaneous with decreases in target levels in follicular cells, several predicted miRNA target interactions were confirmed that are putatively involved in follicular atresia, namely miR-199a-5p/miR-155-HIF1A in granulosa cells, miR-155/miR-222-ETS1 in theca cells, miR-199a-5p-JAG1 in theca cells, miR-199a-5p/miR-150/miR-378-VEGFA in granulosa and theca cells, and miR-155-MSH2 in theca cells. These results offer novel insight on the involvement of miRNAs in follicle development by identifying a miRNA target network that is putatively involved in follicle atresia.
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