Evidence map›Paper›PMID 27664125›Full record

SynthesisJournal of attention disorders2018

Adult ADHD and Comorbid Somatic Disease: A Systematic Literature Review.

Johanne Telnes Instanes, Kari Klungsøyr, Anne Halmøy, Ole Bernt Fasmer, Jan Haavik

Open access · hybridAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of attention disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
107citing papers in PubMed, 5 pooled it
11.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

107 citing papers in PubMed, 5 syntheses or guidelines pooled it, 208 citations in OpenAlex.

  1. Pooled it
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  6. Trial
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  8. Article
  9. Predictors of Somatic Symptom Severity in Adult Psychiatric Outpatients: A Cross-sectional Heart Rate Variability and Quantitative Electroencephalography Study.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2026
    Article
  10. Review
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  12. ADHD and metabolic syndrome: behavioral and weight-related pathways to cardiovascular risk.European archives of psychiatry and clinical neuroscience · 2026
    Article
  13. Review
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  15. Article
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  18. Article
  19. Article
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47 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Johanne Telnes Instanes1 Department of Biomedicine, University of Bergen, Norway.
Kari Klungsøyr2 Department of Global Public Health and Primary Care, University of Bergen, Norway.
Anne Halmøy1 Department of Biomedicine, University of Bergen, Norway.
Ole Bernt Fasmer3 K.G. Jebsen Centre for Neuropsychiatric Disorders, University of Bergen, Norway.
Jan Haavik1 Department of Biomedicine, University of Bergen, Norway.
University of Bergen · NOHaukeland University Hospital · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo systematically review, synthesize, and appraise available evidence, connecting adult ADHD with somatic disease.

methodEmbase, Psychinfo, and Medline databases were searched for studies published from 1994 to 2015 addressing adult ADHD and somatic comorbidity. Somatic conditions were classified according to International Classification of Diseases (ICD-10) codes. Levels of evidence were graded as inconclusive, tentative, or well documented.

resultsMost of the 126 studies included in the qualitative synthesis were small and of modest quality. Obesity, sleep disorders, and asthma were well-documented comorbidities in adult ADHD. Tentative evidence was found for an association between adult ADHD and migraine and celiac disease. In a large health registry study, cardiovascular disease was not associated with adult ADHD.

conclusionThere are few large systematic studies using standardized diagnostic criteria evaluating adult ADHD and somatic comorbidities. Significant associations are found between adult ADHD and several somatic diseases, and these are important to consider when assessing and treating either adult ADHD or the somatic diseases.

Indexed as

AdultAsthmaAttention Deficit Disorder with HyperactivityComorbidityEpilepsyHumansMigraine DisordersObesityRestless Legs SyndromeSleep Wake Disordersadult ADHDasthmamigrainereviewsleep disorders

Identifiers

PMID27664125
PMCPMC5987989
OpenAlexW2521976164

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.