Evidence map›Paper›PMID 27664102›Full record

ArticleJournal of endocrinological investigation2017

Follicular fluid PlGF/sFlt-1 ratio and soluble receptor for advanced glycation end-products correlate with ovarian sensitivity index in women undergoing A.R.T.

H R Nejabati, A Mota, L Farzadi, M Ghojazadeh, A Fattahi, K Hamdi, M Nouri

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Article in Journal of endocrinological investigation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Maternal C-reactive protein and in vitro fertilization (IVF) cycles.Journal of assisted reproduction and genetics · 2020
    Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

H R NejabatiWomen's Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
A MotaDepartment of Clinical Biochemistry, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
L FarzadiWomen's Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
M GhojazadehLiver and Gastrointestinal Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
A FattahiWomen's Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
K HamdiWomen's Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. hamdik@tbzmed.ac.ir.
M NouriWomen's Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. nourimd@yahoo.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeConsidering potential roles of soluble receptor for advanced glycation end products (sRAGE) and placental growth factor (PlGF) in ovarian function and embryo implantation, in the present study we have evaluated the association of these factors and also PlGF/sFlt-1 ratio with the ovarian response and implantation rate by dividing patients according to the OSI.

methodsIn a cross-sectional study, 90 infertile women who were undergoing ICSI cycle using long protocol were recruited. The patients were divided according to ovarian sensitivity index (OSI). ICSI cycle outcomes were evaluated for each patient and PlGF, sFlt-1 and sRAGE levels of follicular fluid were assayed using commercial ELISA kits.

resultsFollicular fluid (FF) sRAGE levels and PlGF/sFlt-1 ratio were statistically greater in high-responder women than other responders (p < 0.05). Positive correlations were obtained between sRAGE level with the number of oocytes, follicles and OSI level. sRAGE levels with cutoff value of 4.83 (ng/ml) for evaluating the pregnancy outcome showed 81.8 % sensitivity and 60.7 % specificity. Furthermore, there were positive associations between PlGF/sFlt-1 ratio with the number of oocytes, embryos and OSI level.

conclusionIn conclusion, the results of current study supported that good ovarian response is independent of pregnancy outcome. Our results showed that FF levels of sRAGE and PlGF/sFlt-1 ratio could be used as markers for determining the high-responder women. Also, FF sRAGE levels could be a good predictor for ART outcome.

Indexed as

AdultBiomarkersCross-Sectional StudiesFemaleFertilization in VitroFollicular FluidFollow-Up StudiesGlycation End Products, AdvancedHumansInfertility, FemaleMaleOocytesOvaryPlacenta Growth FactorPregnancyPrognosisBiomarkersFLT1 protein, humanGlycation End Products, AdvancedPlacenta Growth FactorReceptor for Advanced Glycation End ProductsVascular Endothelial Growth Factor Receptor-1Embryo implantationICSI cycleOvarian responsePlacental growth factorSoluble receptor for advanced glycation end products

Identifiers

PMID27664102

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.