Evidence map›Paper›PMID 27663990›Full record

ReviewAmerican journal of physiology. Lung cellular and molecular physiology2016

Regulation of pulmonary endothelial barrier function by kinases.

Nektarios Barabutis, Alexander Verin, John D Catravas

Open access · bronzeAbstract readReview
In one paragraph

Review in American journal of physiology. Lung cellular and molecular physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 61 citations in OpenAlex.

  1. Article
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  3. Growth hormone - releasing hormone in the immune system.Reviews in endocrine & metabolic disorders · 2025
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  11. Review
  12. Tunicamycin Protects against LPS-Induced Lung Injury.Pharmaceuticals (Basel, Switzerland) · 2022
    Article
  13. Small Extracellular Vesicles Propagate the Inflammatory Response After Trauma.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021
    Article
  14. Article
  15. Article
  16. Article
  17. Secretory Phospholipase ACell biochemistry and biophysics · 2021
    Review
  18. Article
  19. Article
  20. Restoring the endothelial barrier function in the elderly.Mechanisms of ageing and development · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Nektarios BarabutisFrank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, Virginia.
Alexander VerinVascular Biology Center, Augusta University, Augusta, Georgia; and.
John D CatravasFrank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, Virginia, jcatrava@odu.edu.
Old Dominion University · USAugusta University Health · US

Funding

Therapeutic Mechanisms of RhoA Inhibition In Acute Lung InjuryP01HL101902 · NHLBI · AUGUSTA UNIVERSITY · PI BLACK, STEPHEN M · 2011 to 2016
$11.2M
NHLBI NIH HHS P01 HL101902
6 · The paper itself

Abstract

The pulmonary endothelium is the target of continuous physiological and pathological stimuli that affect its crucial barrier function. The regulation, defense, and repair of endothelial barrier function require complex biochemical processes. This review examines the role of endothelial phosphorylating enzymes, kinases, a class with profound, interdigitating influences on endothelial permeability and lung function.

Indexed as

AnimalsEndothelium, VascularHumansLungProtein KinasesSignal TransductionProtein Kinasesbarrier functionendotheliumkinaseslungpermeability

Identifiers

PMID27663990
PMCPMC5130537
OpenAlexW2522746387

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.