ArticleGenome biology2016
Novel regional age-associated DNA methylation changes within human common disease-associated loci.
Article in Genome biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- From aging to Alzheimer's disease: concordant brain DNA methylation changes in late life.Genome medicine · 2026Article
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- Review
- Gut microbiota and epigenetic age acceleration: a bi-directional Mendelian randomization study.Aging clinical and experimental research · 2024Article
- MIAMI-AD (Methylation in Aging and Methylation in AD): an integrative knowledgebase that facilitates explorations of DNA methylation across sex, aging, and Alzheimer's disease.Database : the journal of biological databases and curation · 2024Article
- Epigenomic insights into common human disease pathology.Cellular and molecular life sciences : CMLS · 2024Review
- Genetic impacts on DNA methylation help elucidate regulatory genomic processes.Genome biology · 2023Article
- Article
- tRNA dysregulation and disease.Nature reviews. Genetics · 2022Review
- Comprehensive analysis of epigenetic clocks reveals associations between disproportionate biological ageing and hippocampal volume.GeroScience · 2022Article
- The genomic loci of specific human tRNA genes exhibit ageing-related DNA hypermethylation.Nature communications · 2021Article
- Accelerating the Search for Interventions Aimed at Expanding the Health Span in Humans: The Role of Epidemiology.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Review
- DNA methylation aging clocks: challenges and recommendations.Genome biology · 2019Review
- The effect of age on DNA methylation in whole blood among Bangladeshi men and women.BMC genomics · 2019Article
- Novel age-associated DNA methylation changes and epigenetic age acceleration in middle-aged African Americans and whites.Clinical epigenetics · 2019Article
- The Impact of Caloric Restriction on the Epigenetic Signatures of Aging.International journal of molecular sciences · 2019Review
- The relationships and interactions between age, exercise and physiological function.The Journal of physiology · 2019Review
- Methylation Marks of Blood Leukocytes of Native Hucul Mares Differentiated in Age.International journal of genomics · 2019Article
- Obligatory and facilitative allelic variation in the DNA methylome within common disease-associated loci.Nature communications · 2018Article
- INSIG2 rs7566605 single nucleotide variant and global DNA methylation index levels are associated with weight loss in a personalized weight reduction program.Molecular medicine reports · 2018Article
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Authors and funding
11 authors.
Funding
Abstract
backgroundAdvancing age progressively impacts on risk and severity of chronic disease. It also modifies the epigenome, with changes in DNA methylation, due to both random drift and variation within specific functional loci.
resultsIn a discovery set of 2238 peripheral-blood genome-wide DNA methylomes aged 19-82 years, we identify 71 age-associated differentially methylated regions within the linkage disequilibrium blocks of the single nucleotide polymorphisms from the NIH genome-wide association study catalogue. This included 52 novel regions, 29 within loci not covered by 450 k or 27 k Illumina array, and with enrichment for DNase-I Hypersensitivity sites across the full range of tissues. These age-associated differentially methylated regions also show marked enrichment for enhancers and poised promoters across multiple cell types. In a replication set of 2084 DNA methylomes, 95.7 % of the age-associated differentially methylated regions showed the same direction of ageing effect, with 80.3 % and 53.5 % replicated to p < 0.05 and p < 1.85 × 10
conclusionBy analysing the functionally enriched disease and trait-associated regions of the human genome, we identify novel epigenetic ageing changes, which could be useful biomarkers or provide mechanistic insights into age-related common diseases.
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