ArticleIn vitro cellular & developmental biology. Animal2017
Upregulated microRNA-224 promotes ovarian cancer cell proliferation by targeting KLLN.
Article in In vitro cellular & developmental biology. Animal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- LncRNA SEMA3B-AS1 inhibits breast cancer progression by targeting miR-3940/KLLN axis.Cell death & disease · 2022Article
- Investigating melanogenesis-related microRNAs as disease biomarkers in vitiligo.Scientific reports · 2022Article
- Identification and differential expression of microRNAs in Madin-Darby canine kidney cells with high and low tumorigenicities.Genes & genomics · 2022Article
- Long non-coding RNA NEAT1 facilitates the growth, migration, and invasion of ovarian cancer cells via the let-7 g/MEST/ATGL axis.Cancer cell international · 2021Article
- Roles of Noncoding RNA in Reproduction.Frontiers in genetics · 2021Review
- Identification of nuclear export signal in KLLN suggests potential role in proteasomal degradation in cancer cells.Oncotarget · 2020Article
- CircRNA expression profiles in decidual tissue of patients with early recurrent miscarriage.Genes & diseases · 2020Article
- MicroRNA-204 may participate in the pathogenesis of hypoxic-ischemic encephalopathy through targeting KLLN.Experimental and therapeutic medicine · 2019Article
- LINC00472 Acts as a Tumor Suppressor in NSCLC through KLLN-Mediated p53-Signaling Pathway via MicroRNA-149-3p and MicroRNA-4270.Molecular therapy. Nucleic acids · 2019Article
- Upregulated lncRNA Gm2044 inhibits male germ cell development by acting as miR-202 host gene.Animal cells and systems · 2019Article
- miR-221 regulates proliferation and apoptosis of ovarian cancer cells by targeting BMF.Oncology letters · 2018Article
- MicroRNA‑665 suppresses the growth and migration of ovarian cancer cells by targeting HOXA10.Molecular medicine reports · 2018Article
- miR-224 enhances invasion and metastasis by targeting HOXD10 in non-small cell lung cancer cells.Oncology letters · 2018Article
- miR-205 regulates the proliferation and invasion of ovarian cancer cells via suppressing PTEN/SMAD4 expression.Oncology letters · 2018Article
- MicroRNA‑497 inhibits cellular proliferation, migration and invasion of papillary thyroid cancer by directly targeting AKT3.Molecular medicine reports · 2017Article
- Clinical value and potential targets of miR-224-5p in hepatocellular carcinoma validated by a TCGA- and GEO- based study.International journal of clinical and experimental pathology · 2017Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human epithelial ovarian cancer is a complex disease, with low 5-yr survival rate largely due to the terminal stage at diagnosis in most patients. MicroRNAs play critical roles during epithelial ovarian cancer progression in vivo and have also been shown to regulate characteristic of ovarian cancer cell line in vitro. Alterative microRNA-224 (microRNA-224) expression affects human epithelial ovarian cancer cell survival, apoptosis, and metastasis. However, people know little about the effects of microRNA-224 on epithelial ovarian cancer cell proliferation. In the current study, we found that the microRNA-224 expression level of human syngeneic epithelial ovarian cancer cells HO8910 (low metastatic ability) was lower than that of HO8910PM (high metastatic ability). Furthermore, microRNA-224 was confirmed to target KLLN in HO8910 and HO8910PM. The known KLLN downstream target cyclin A was regulated by microRNA-224 in HO8910 and HO8910PM. In addition, overexpression of microRNA-224 enhanced the proliferation abilities of HO8910 and knockdown of microRNA-224 suppressed the proliferation abilities of HO8910PM by KLLN-cyclin A pathway. Our results provide new data about microRNAs and their targets involved in proliferation of epithelial ovarian cancer cells by modulating the downstream signaling.
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