Evidence map›Paper›PMID 27663743›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2016

Oriented collagen fibers direct tumor cell intravasation.

Weijing Han, Shaohua Chen, Wei Yuan, Qihui Fan, Jianxiang Tian, Xiaochen Wang, Longqing Chen, Xixiang Zhang, Weili Wei, Ruchuan Liu and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 217 papers.

0numbers the graph read from it
0cells of the map it votes in
217citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

217 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Microphysiological systems for metastasis research: a stepwise approach.Cellular oncology (Dordrecht, Netherlands) · 2025
    Review
  14. Review
  15. Deep learning reveals how cells pull, buckle, and navigate fibrous environments.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  16. Article
  17. The Duality of Collagens in Metastases of Solid Tumors.International journal of molecular sciences · 2025
    Review
  18. Article
  19. Article
  20. Article

157 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Weijing HanKey Laboratory of Soft Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing, China 100190.
Shaohua ChenMaterials Science and Engineering, Arizona State University, Tempe, AZ 85281.
Wei YuanKey Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, Shenzhen University, Shenzhen, China 518060.
Qihui FanKey Laboratory of Soft Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing, China 100190.
Jianxiang TianMaterials Science and Engineering, Arizona State University, Tempe, AZ 85281.
Xiaochen WangKey Laboratory of Soft Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing, China 100190.
Longqing ChenDivision of Physical Science and Engineering, King Abdullah University of Science & Technology, Thuwal, Saudi Arabia 23955-6900.
Xixiang ZhangInnovative Drug Research Center, Chongqing University, Chongqing, China 401331.
Weili WeiInnovative Drug Research Center, Chongqing University, Chongqing, China 401331.
Ruchuan LiuCollege of Physics, Chongqing University, Chongqing, China 401331.
Junle QuKey Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, Shenzhen University, Shenzhen, China 518060.
Yang JiaoMaterials Science and Engineering, Arizona State University, Tempe, AZ 85281.
Robert H AustinDepartment of Physics, Princeton University, Princeton, NJ 08544 Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, Shenzhen University, Shenzhen, China 518060; lyliu@cqu.edu.cn austin@princeton.edu.
Liyu LiuCollege of Physics, Chongqing University, Chongqing, China 401331; Key Laboratory of Soft Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing, China 100190; lyliu@cqu.edu.cn austin@princeton.edu.

Funding

TRANS_NETWORK PROJECTSU54CA143803 · NCI · PRINCETON UNIVERSITY · PI TLSTY, THEA D · 2009 to 2013
$14.2M
NCI NIH HHS U54 CA143803
6 · The paper itself

Abstract

In this work, we constructed a Collagen I-Matrigel composite extracellular matrix (ECM). The composite ECM was used to determine the influence of the local collagen fiber orientation on the collective intravasation ability of tumor cells. We found that the local fiber alignment enhanced cell-ECM interactions. Specifically, metastatic MDA-MB-231 breast cancer cells followed the local fiber alignment direction during the intravasation into rigid Matrigel (∼10 mg/mL protein concentration).

Indexed as

BiopsyCell Line, TumorCell ProliferationCollagenDisease ProgressionExtracellular MatrixFemaleHumansNeoplasm MetastasisNeoplasmsTime-Lapse ImagingCollagencancercollagenintravasationmicroenvironmentoriented invasion

Identifiers

PMID27663743
PMCPMC5056065

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.