Evidence map›Paper›PMID 27663718›Full record

ArticleObesity (Silver Spring, Md.)2016

Genetic variation near IRS1 is associated with adiposity and a favorable metabolic profile in U.S. Hispanics/Latinos.

Qibin Qi, Stephanie M Gogarten, Leslie S Emery, Tin Louie, Adrienne Stilp, Jianwen Cai, Neil Schneiderman, M Larissa Avilés-Santa, Robert C Kaplan, Kari E North and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Obesity (Silver Spring, Md.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 1 country.

Qibin QiDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, USA. qibin.qi@einstein.yu.edu.
Stephanie M GogartenDepartment of Biostatistics, University of Washington, Seattle, Washington, USA.ORCID 0000-0002-7231-9745
Leslie S EmeryDepartment of Biostatistics, University of Washington, Seattle, Washington, USA.
Tin LouieDepartment of Biostatistics, University of Washington, Seattle, Washington, USA.
Adrienne StilpDepartment of Biostatistics, University of Washington, Seattle, Washington, USA.
Jianwen CaiDepartment of Biostatistics and Collaborative Studies Coordinating Center, University of North Carolina, Chapel Hill, North Carolina, USA.
Neil SchneidermanDepartment of Psychology, University of Miami, Miami, Florida, USA.
M Larissa Avilés-SantaDivision of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
Robert C KaplanDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, USA.
Kari E NorthDepartment of Epidemiology and Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, North Carolina, USA.
Cathy C LaurieDepartment of Biostatistics, University of Washington, Seattle, Washington, USA.
Ruth J F LoosDepartment of Preventive Medicine, Icahn School of Medicine at Mount Sinai, New York City, New York, USA.
Carmen R IsasiDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, USA.
University of Washington · USAlbert Einstein College of Medicine · USUniversity of North Carolina at Chapel Hill · USIcahn School of Medicine at Mount Sinai · USNational Institutes of Health · USUniversity of Miami · US

Funding

Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4M
Translational Research CoreP30DK020541 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI STREAMSON C CHUA · 2015 to 2026
$27.7M
Core-010UL1TR001073 · NCATS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI KELLER, MARLA J, SHAMOON, HARRY · 2013 to 2017
$21.3M
Clinical and Translational Science Coordinating CenterU54TR000123 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2017
$14.2M
Thalassemia Clinical Research Network, CanadaU01HL065233 · NHLBI · UNIVERSITY HEALTH NETWORK · PI OLIVIERI, NANCY F · 2000 to 2009
$2.6M
GENETIC ARCHITECTURE OF PLASMA T-PA AND PAI-1R01HL065234 · NHLBI · VANDERBILT UNIVERSITY · PI MOORE, JASON H. · 2000 to 2004
$1.7M
HIV Infection, Metabolites and Subclinical AtherosclerosisK01HL129892 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI QI, QIBIN · 2015 to 2018
$637k
HISPANIC COMMUNITY HEALTH STUDY-268065233N01HC065233 · HC · COORDINATING CENTER · PI CHAMBLESS, LLOYD E · 2006 to 2006
–
NCATS NIH HHS U54 TR000123NCATS NIH HHS UL1 TR001073NHLBI NIH HHS HHSN268201300005CNHLBI NIH HHS K01 HL129892NHLBI NIH HHS N01 HC065233NHLBI NIH HHS N01 HC065234NHLBI NIH HHS N01 HC065235NHLBI NIH HHS N01 HC065236NHLBI NIH HHS N01 HC065237NIDDK NIH HHS P30 DK020541NIDDK NIH HHS P30 DK063491
6 · The paper itself

Abstract

objectiveAssociations of IRS1 genetic variation with adiposity and metabolic profile in U.S. Hispanic/Latino individuals of diverse backgrounds were examined.

methodsPreviously genome-wide association study-identified IRS1 variants (rs2943650, rs2972146, rs2943641, and rs2943634) as related to body fat percentage (BF%) and multiple metabolic traits were tested among up to 12,730 adults (5,232 men; 7,515 women) from the Hispanic Community Health Study/Study of Latinos.

resultsThe C-allele (frequency = 26%) of rs2943650 was significantly associated with higher BF% overall (β = 0.34 ± 0.11% per allele; P = 0.002) and in women (β = 0.41 ± 0.14% per C-allele; P = 0.003), but not in men (β = 0.28 ± 0.18% per C-allele; P = 0.11), though there was no significant sex difference. Using the inverse normal-transformed data to compare effect sizes, it was found that the association with BF% was stronger in Hispanic/Latino women than that previously reported in European women (β = 0.054 ± 0.018SD vs. β = 0.008 ± 0.011SD per C-allele; P = 0.03). The BF%-increasing allele of rs2943650 was significantly associated with lower levels of fasting insulin, homeostatic model assessment of insulin resistance, hemoglobin A1c, and triglycerides and higher high-density lipoprotein cholesterol (P < 0.05).

conclusionsThis study confirmed and extended previous findings of IRS1 variation associated with increased adiposity but a favorable metabolic profile in U.S. Hispanics/Latinos, with a relatively stronger genetic effect on BF% in Hispanic/Latino women compared with European women.

Indexed as

Genetic VariationMetabolomeAdiposityAdultAllelesCholesterol, HDLEthnicityFastingFemaleGene FrequencyGenome-Wide Association StudyGlycated HemoglobinHispanic or LatinoHumansInsulinInsulin Receptor Substrate ProteinsCholesterol, HDLGlycated HemoglobinInsulinInsulin Receptor Substrate ProteinsIRS1 protein, humanTriglycerides

Identifiers

PMID27663718
PMCPMC5093062
OpenAlexW2524184295

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.