Evidence map›Paper›PMID 27663696›Full record

ArticleEating and weight disorders : EWD2018

The association between follicle stimulating hormone and glutathione peroxidase activity is dependent on abdominal obesity in postmenopausal women.

Aleksandra Klisic, Jelena Kotur-Stevuljevic, Nebojsa Kavaric, Milica Martinovic, Marija Matic

Abstract read
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In one paragraph

Article in Eating and weight disorders : EWD, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 27 citations in OpenAlex.

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  5. Are total bilirubin and high-sensitivity C-reactive protein independently associated with Type 2 diabetes mellitus in postmenopausal women?Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Aleksandra KlisicPrimary Health Care Center, Trg Nikole Kovacevica 6, 81000, Podgorica, Montenegro. aleksandranklisic@gmail.com.
Jelena Kotur-StevuljevicDepartment for Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia.
Nebojsa KavaricPrimary Health Care Center, Trg Nikole Kovacevica 6, 81000, Podgorica, Montenegro.
Milica MartinovicDepartment for Pathophysiology and Laboratory Medicine, Medical Faculty, University of Montenegro, Podgorica, Montenegro.
Marija MaticFaculty of Medicine, Institute of Medical and Clinical Biochemistry, University of Belgrade, Belgrade, Serbia.
University of Montenegro · MEUniversity of Belgrade · RS

Funding

Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja (RS) OI 175035
6 · The paper itself

Abstract

purposeMenopause is frequently associated with an increase in visceral fat, thus modifying redox status by promoting oxidative damage and decreasing antioxidant defense systems. It is known that at higher concentrations estradiol has some antioxidant properties, while its decline in postmenopause is associated with pro-oxidant effects. However, the role of follicle stimulating hormone (FSH) in antioxidant defense in postmenopausal women is still not well elucidated. Therefore, we aimed to evaluate the potential complex association between visceral obesity, FSH and enzymatic antioxidant defense as measured by glutathione peroxidase (GPx) in postmenopausal women.

methodsA total of 150 postmenopausal women (mean age 56.6 ± 4.8 years), among them 50 normal weight and 100 overweight/obese, were included. GPx activity, FSH, luteinizing hormone, estradiol, total testosterone, cardiometabolic and anthropometric parameters, were determined.

resultsWith increasing tertiles of serum FSH levels, significant increase in GPx activity (P = 0.005) was found. Also, the highest number of overweight/obese subjects were in the group with the lowest FSH values (χ

conclusionHigher GPx activity is associated with higher FSH level, but abdominal obesity may be the underlying determinant of this relationship.

Indexed as

Blood PressureEstradiolFemaleFollicle Stimulating HormoneGlutathione PeroxidaseHumansInsulin ResistanceLuteinizing HormoneMiddle AgedObesity, AbdominalPostmenopauseWaist CircumferenceEstradiolFollicle Stimulating HormoneGlutathione PeroxidaseLuteinizing HormoneAntioxidant defenseFollicle stimulating hormoneObesityPostmenopausal women

Identifiers

PMID27663696
OpenAlexW2522381316

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.