ArticleJournal of endodontics2016
Triple Antibiotic Polymer Nanofibers for Intracanal Drug Delivery: Effects on Dual Species Biofilm and Cell Function.
Article in Journal of endodontics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 50 citations in OpenAlex.
- Antimicrobial effects of Propolis, calcium Hydroxide, triple antibiotic paste, and modified triple antibiotic paste on tubular dentin inoculated with a dual-species biofilm: an ex vivo study.BMC oral health · 2026Article
- Efficacy of Ciprofloxacin, Metronidazole and Minocycline in Ordered Mesoporous Silica againstMaterials (Basel, Switzerland) · 2022Article
- Mesenchymal Stem Cells Based Treatment in Dental Medicine: A Narrative Review.International journal of molecular sciences · 2022Review
- Nanofibrous scaffolds for regenerative endodontics treatment.Frontiers in bioengineering and biotechnology · 2022Review
- Preparation, Physicochemical Assessment and the Antimicrobial Action of Hydroxyapatite-Gelatin/Curcumin Nanofibrous Composites as a Dental Biomaterial.Biomimetics (Basel, Switzerland) · 2021Article
- Platform technologies for regenerative endodontics from multifunctional biomaterials to tooth-on-a-chip strategies.Clinical oral investigations · 2021Review
- In Vitro Development of a New Sponge-Based Delivery System for Intracanal Antimicrobial Administration in Endodontic Treatment.Journal of clinical medicine · 2021Article
- A novel antimicrobial-containing nanocellulose scaffold for regenerative endodontics.Restorative dentistry & endodontics · 2021Article
- Antibacterial agent-releasing scaffolds in dental tissue engineering.Journal of advanced periodontology & implant dentistry · 2021Review
- Antimicrobial Therapeutics in Regenerative Endodontics: A Scoping Review.Journal of endodontics · 2020Article
- The Effects of Intracanal Irrigants and Medicaments on Dental-Derived Stem Cells Fate in Regenerative Endodontics: An update.Stem cell reviews and reports · 2020Review
- Curcumin-A Natural Medicament for Root Canal Disinfection: Effects of Irrigation, Drug Release, and Photoactivation.Journal of endodontics · 2019Article
- Comparative Evaluation of the Cytotoxic and Angiogenic Effects of Minocycline and Clindamycin: An In Vitro Study.Journal of endodontics · 2019Article
- A novel patient-specific three-dimensional drug delivery construct for regenerative endodontics.Journal of biomedical materials research. Part B, Applied biomaterials · 2019Article
- Strategic Tools in Regenerative and Translational Dentistry.International journal of molecular sciences · 2019Review
- Animal Models for Stem Cell-Based Pulp Regeneration: Foundation for Human Clinical Applications.Tissue engineering. Part B, Reviews · 2019Review
- The antimicrobial properties, cytotoxicity, and differentiation potential of double antibiotic intracanal medicaments loaded into hydrogel system.Clinical oral investigations · 2019Article
- Trends in polymeric electrospun fibers and their use as oral biomaterials.Experimental biology and medicine (Maywood, N.J.) · 2018Review
- Clindamycin-modified Triple Antibiotic Nanofibers: A Stain-free Antimicrobial Intracanal Drug Delivery System.Journal of endodontics · 2018Article
- Advanced Scaffolds for Dental Pulp and Periodontal Regeneration.Dental clinics of North America · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
introductionRoot canal disinfection and the establishment of an intracanal microenvironment conducive to the proliferation/differentiation of stem cells play a significant role in regenerative endodontics. This study was designed to (1) investigate the antimicrobial efficacy of triple antibiotic-containing nanofibers against a dual-species biofilm and (2) evaluate the ability of dental pulp stem cells (DPSCs) to adhere to and proliferate on dentin upon nanofiber exposure.
methodsSeven-day-old dual-species biofilm established on dentin specimens was exposed for 3 days to the following: saline (control), antibiotic-free nanofibers (control), and triple antibiotic-containing nanofibers or a saturated triple antibiotic paste (TAP) solution (50 mg/mL in phosphate buffer solution). Bacterial viability was assessed using the LIVE/DEAD assay (Molecular Probes, Inc, Eugene, OR) and confocal laser scanning microscopy. For cytocompatibility studies, dentin specimens after nanofiber or TAP (1 g/mL in phosphate buffer solution) exposure were evaluated for cell adhesion and spreading by actin-phalloidin staining. DPSC proliferation was assessed on days 1, 3, and 7. Statistics were performed, and significance was set at the 5% level.
resultsConfocal laser scanning microscopy showed significant bacterial death upon antibiotic-containing nanofiber exposure, differing significantly (P < .05) from antibiotic-free fibers and the control (saline). DPSCs showed enhanced adhesion/spreading on dentin specimens treated with antibiotic-containing nanofibers when compared with its TAP counterparts. The DPSC proliferation rate was similar on days 1 and 3 in antibiotic-free nanofibers, triple antibiotic-containing nanofibers, and TAP-treated dentin. Proliferation was higher (9-fold) on dentin treated with antibiotic-containing nanofibers on day 7 compared with TAP.
conclusionsTriple antibiotic-containing polymer nanofibers led to significant bacterial death, whereas they did not affect DPSC attachment and proliferation on dentin.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.