Evidence map›Paper›PMID 27663500›Full record

ArticleBioinformatics (Oxford, England)2017

FoldAtlas: a repository for genome-wide RNA structure probing data.

Matthew Norris, Chun Kit Kwok, Jitender Cheema, Matthew Hartley, Richard J Morris, Sharon Aviran, Yiliang Ding

Open access · hybridAbstract read
In one paragraph

Article in Bioinformatics (Oxford, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Genome-Wide RNA Secondary Structure Prediction.Methods in molecular biology (Clifton, N.J.) · 2023
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Probing RNA structure in vivo.Current opinion in structural biology · 2019
    Review
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Matthew NorrisJohn Innes Centre, Norwich Research Park, Norwich, UK.
Chun Kit KwokDepartment of Biology and Chemistry, City University of Hong Kong, Kowloon Tong, Hong Kong SAR, China.
Jitender CheemaJohn Innes Centre, Norwich Research Park, Norwich, UK.
Matthew HartleyJohn Innes Centre, Norwich Research Park, Norwich, UK.
Richard J MorrisJohn Innes Centre, Norwich Research Park, Norwich, UK.
Sharon AviranDepartment of Biomedical Engineering and Genome Center, UC Davis, Davis, CA, USA.
Yiliang DingJohn Innes Centre, Norwich Research Park, Norwich, UK.
John Innes Centre · GBCity University of Hong Kong · HKNorwich Research Park · GBUniversity of California, Davis · US

Funding

Methods for RNA structural analysis using computation and structure mapping experR00HG006860 · NHGRI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI AVIRAN, SHARON · 2014 to 2016
$725k
Methods for RNA structural analysis using computation and structure mapping experK99HG006860 · NHGRI · UNIVERSITY OF CALIFORNIA BERKELEY · PI AVIRAN, SHARON · 2012 to 2012
$103k
Biotechnology and Biological Sciences Research Council BB/L025000/1Biotechnology and Biological Sciences Research Council BB/N022572/1Biotechnology and Biological Sciences Research Council BBS/E/J/000C0641Biotechnology and Biological Sciences Research Council BBS/E/J/000PR9788NHGRI NIH HHS K99 HG006860NHGRI NIH HHS R00 HG006860
6 · The paper itself

Abstract

Most RNA molecules form internal base pairs, leading to a folded secondary structure. Some of these structures have been demonstrated to be functionally significant. High-throughput RNA structure chemical probing methods generate millions of sequencing reads to provide structural constraints for RNA secondary structure prediction. At present, processed data from these experiments are difficult to access without computational expertise. Here we present FoldAtlas, a web interface for accessing raw and processed structural data across thousands of transcripts. FoldAtlas allows a researcher to easily locate, view, and retrieve probing data for a given RNA molecule. We also provide in silico and in vivo secondary structure predictions for comparison, visualized in the browser as circle plots and topology diagrams. Data currently integrated into FoldAtlas are from a new high-depth Structure-seq data analysis in Arabidopsis thaliana, released with this work. AVAILABILITY AND IMPLEMENTATION: The FoldAtlas website can be accessed at www.foldatlas.com Source code is freely available at github.com/mnori/foldatlas under the MIT license. Raw reads data are available under the NCBI SRA accession SRP066985. CONTACT: yiliang.ding@jic.ac.uk or matthew.norris@jic.ac.ukSupplementary information: Supplementary data are available at Bioinformatics online.

Indexed as

Databases, Nucleic AcidArabidopsisComputer SimulationNucleic Acid ConformationRNARNA, PlantSequence Analysis, RNARNARNA, Plant

Identifiers

PMID27663500
PMCPMC5254078
OpenAlexW2522335941

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.