Evidence map›Paper›PMID 27662847›Full record

ArticleCirculation. Cardiovascular interventions2016

Implantation of the Medtronic Harmony Transcatheter Pulmonary Valve Improves Right Ventricular Size and Function in an Ovine Model of Postoperative Chronic Pulmonary Insufficiency.

Rosanne C Schoonbeek, Satoshi Takebayashi, Chikashi Aoki, Toru Shimaoka, Matthew A Harris, Gregory L Fu, Timothy S Kim, Yoav Dori, Jeremy McGarvey, Harold Litt and 7 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation. Cardiovascular interventions, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Percutaneous Pulmonary Valve Implantation.Korean circulation journal · 2020
    Review
  6. Toward predictive modeling of catheter-based pulmonary valve replacement into native right ventricular outflow tracts.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2019
    Article
  7. Review
  8. Review
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 1 institution in 1 country.

Rosanne C SchoonbeekFrom the Gorman Cardiovascular Research Group, Department of Surgery, The Children's Hospital of Philadelphia, PA (R.C.S., S.T., C.A., T.S., J.M., W.B., G.Z., R.C.G., J.H.G., M.J.G.); Department of Cardiology (M.A.H., G.L.F., T.S.K, Y.D., A.C.G, J.J.R., M.J.G.) and Department Radiology (H.L.), Perelman School of Medicine, University of Pennsylvania, Philadelphia; and Department of Cardiothoracic Surgery, University Medical Center Groningen, University of Groningen, the Netherlands (R.C.S., W.B.).
Satoshi TakebayashiFrom the Gorman Cardiovascular Research Group, Department of Surgery, The Children's Hospital of Philadelphia, PA (R.C.S., S.T., C.A., T.S., J.M., W.B., G.Z., R.C.G., J.H.G., M.J.G.); Department of Cardiology (M.A.H., G.L.F., T.S.K, Y.D., A.C.G, J.J.R., M.J.G.) and Department Radiology (H.L.), Perelman School of Medicine, University of Pennsylvania, Philadelphia; and Department of Cardiothoracic Surgery, University Medical Center Groningen, University of Groningen, the Netherlands (R.C.S., W.B.).
Chikashi AokiFrom the Gorman Cardiovascular Research Group, Department of Surgery, The Children's Hospital of Philadelphia, PA (R.C.S., S.T., C.A., T.S., J.M., W.B., G.Z., R.C.G., J.H.G., M.J.G.); Department of Cardiology (M.A.H., G.L.F., T.S.K, Y.D., A.C.G, J.J.R., M.J.G.) and Department Radiology (H.L.), Perelman School of Medicine, University of Pennsylvania, Philadelphia; and Department of Cardiothoracic Surgery, University Medical Center Groningen, University of Groningen, the Netherlands (R.C.S., W.B.).
Toru ShimaokaFrom the Gorman Cardiovascular Research Group, Department of Surgery, The Children's Hospital of Philadelphia, PA (R.C.S., S.T., C.A., T.S., J.M., W.B., G.Z., R.C.G., J.H.G., M.J.G.); Department of Cardiology (M.A.H., G.L.F., T.S.K, Y.D., A.C.G, J.J.R., M.J.G.) and Department Radiology (H.L.), Perelman School of Medicine, University of Pennsylvania, Philadelphia; and Department of Cardiothoracic Surgery, University Medical Center Groningen, University of Groningen, the Netherlands (R.C.S., W.B.).
Matthew A HarrisFrom the Gorman Cardiovascular Research Group, Department of Surgery, The Children's Hospital of Philadelphia, PA (R.C.S., S.T., C.A., T.S., J.M., W.B., G.Z., R.C.G., J.H.G., M.J.G.); Department of Cardiology (M.A.H., G.L.F., T.S.K, Y.D., A.C.G, J.J.R., M.J.G.) and Department Radiology (H.L.), Perelman School of Medicine, University of Pennsylvania, Philadelphia; and Department of Cardiothoracic Surgery, University Medical Center Groningen, University of Groningen, the Netherlands (R.C.S., W.B.).
Gregory L FuFrom the Gorman Cardiovascular Research Group, Department of Surgery, The Children's Hospital of Philadelphia, PA (R.C.S., S.T., C.A., T.S., J.M., W.B., G.Z., R.C.G., J.H.G., M.J.G.); Department of Cardiology (M.A.H., G.L.F., T.S.K, Y.D., A.C.G, J.J.R., M.J.G.) and Department Radiology (H.L.), Perelman School of Medicine, University of Pennsylvania, Philadelphia; and Department of Cardiothoracic Surgery, University Medical Center Groningen, University of Groningen, the Netherlands (R.C.S., W.B.).
Timothy S KimFrom the Gorman Cardiovascular Research Group, Department of Surgery, The Children's Hospital of Philadelphia, PA (R.C.S., S.T., C.A., T.S., J.M., W.B., G.Z., R.C.G., J.H.G., M.J.G.); Department of Cardiology (M.A.H., G.L.F., T.S.K, Y.D., A.C.G, J.J.R., M.J.G.) and Department Radiology (H.L.), Perelman School of Medicine, University of Pennsylvania, Philadelphia; and Department of Cardiothoracic Surgery, University Medical Center Groningen, University of Groningen, the Netherlands (R.C.S., W.B.).
Yoav DoriFrom the Gorman Cardiovascular Research Group, Department of Surgery, The Children's Hospital of Philadelphia, PA (R.C.S., S.T., C.A., T.S., J.M., W.B., G.Z., R.C.G., J.H.G., M.J.G.); Department of Cardiology (M.A.H., G.L.F., T.S.K, Y.D., A.C.G, J.J.R., M.J.G.) and Department Radiology (H.L.), Perelman School of Medicine, University of Pennsylvania, Philadelphia; and Department of Cardiothoracic Surgery, University Medical Center Groningen, University of Groningen, the Netherlands (R.C.S., W.B.).
Jeremy McGarveyFrom the Gorman Cardiovascular Research Group, Department of Surgery, The Children's Hospital of Philadelphia, PA (R.C.S., S.T., C.A., T.S., J.M., W.B., G.Z., R.C.G., J.H.G., M.J.G.); Department of Cardiology (M.A.H., G.L.F., T.S.K, Y.D., A.C.G, J.J.R., M.J.G.) and Department Radiology (H.L.), Perelman School of Medicine, University of Pennsylvania, Philadelphia; and Department of Cardiothoracic Surgery, University Medical Center Groningen, University of Groningen, the Netherlands (R.C.S., W.B.).
Harold LittFrom the Gorman Cardiovascular Research Group, Department of Surgery, The Children's Hospital of Philadelphia, PA (R.C.S., S.T., C.A., T.S., J.M., W.B., G.Z., R.C.G., J.H.G., M.J.G.); Department of Cardiology (M.A.H., G.L.F., T.S.K, Y.D., A.C.G, J.J.R., M.J.G.) and Department Radiology (H.L.), Perelman School of Medicine, University of Pennsylvania, Philadelphia; and Department of Cardiothoracic Surgery, University Medical Center Groningen, University of Groningen, the Netherlands (R.C.S., W.B.).
Wobbe BoumaFrom the Gorman Cardiovascular Research Group, Department of Surgery, The Children's Hospital of Philadelphia, PA (R.C.S., S.T., C.A., T.S., J.M., W.B., G.Z., R.C.G., J.H.G., M.J.G.); Department of Cardiology (M.A.H., G.L.F., T.S.K, Y.D., A.C.G, J.J.R., M.J.G.) and Department Radiology (H.L.), Perelman School of Medicine, University of Pennsylvania, Philadelphia; and Department of Cardiothoracic Surgery, University Medical Center Groningen, University of Groningen, the Netherlands (R.C.S., W.B.).
Gerald ZsidoFrom the Gorman Cardiovascular Research Group, Department of Surgery, The Children's Hospital of Philadelphia, PA (R.C.S., S.T., C.A., T.S., J.M., W.B., G.Z., R.C.G., J.H.G., M.J.G.); Department of Cardiology (M.A.H., G.L.F., T.S.K, Y.D., A.C.G, J.J.R., M.J.G.) and Department Radiology (H.L.), Perelman School of Medicine, University of Pennsylvania, Philadelphia; and Department of Cardiothoracic Surgery, University Medical Center Groningen, University of Groningen, the Netherlands (R.C.S., W.B.).
Andrew C GlatzFrom the Gorman Cardiovascular Research Group, Department of Surgery, The Children's Hospital of Philadelphia, PA (R.C.S., S.T., C.A., T.S., J.M., W.B., G.Z., R.C.G., J.H.G., M.J.G.); Department of Cardiology (M.A.H., G.L.F., T.S.K, Y.D., A.C.G, J.J.R., M.J.G.) and Department Radiology (H.L.), Perelman School of Medicine, University of Pennsylvania, Philadelphia; and Department of Cardiothoracic Surgery, University Medical Center Groningen, University of Groningen, the Netherlands (R.C.S., W.B.).
Jonathan J RomeFrom the Gorman Cardiovascular Research Group, Department of Surgery, The Children's Hospital of Philadelphia, PA (R.C.S., S.T., C.A., T.S., J.M., W.B., G.Z., R.C.G., J.H.G., M.J.G.); Department of Cardiology (M.A.H., G.L.F., T.S.K, Y.D., A.C.G, J.J.R., M.J.G.) and Department Radiology (H.L.), Perelman School of Medicine, University of Pennsylvania, Philadelphia; and Department of Cardiothoracic Surgery, University Medical Center Groningen, University of Groningen, the Netherlands (R.C.S., W.B.).
Robert C GormanFrom the Gorman Cardiovascular Research Group, Department of Surgery, The Children's Hospital of Philadelphia, PA (R.C.S., S.T., C.A., T.S., J.M., W.B., G.Z., R.C.G., J.H.G., M.J.G.); Department of Cardiology (M.A.H., G.L.F., T.S.K, Y.D., A.C.G, J.J.R., M.J.G.) and Department Radiology (H.L.), Perelman School of Medicine, University of Pennsylvania, Philadelphia; and Department of Cardiothoracic Surgery, University Medical Center Groningen, University of Groningen, the Netherlands (R.C.S., W.B.).
Joseph H GormanFrom the Gorman Cardiovascular Research Group, Department of Surgery, The Children's Hospital of Philadelphia, PA (R.C.S., S.T., C.A., T.S., J.M., W.B., G.Z., R.C.G., J.H.G., M.J.G.); Department of Cardiology (M.A.H., G.L.F., T.S.K, Y.D., A.C.G, J.J.R., M.J.G.) and Department Radiology (H.L.), Perelman School of Medicine, University of Pennsylvania, Philadelphia; and Department of Cardiothoracic Surgery, University Medical Center Groningen, University of Groningen, the Netherlands (R.C.S., W.B.).
Matthew J GillespieFrom the Gorman Cardiovascular Research Group, Department of Surgery, The Children's Hospital of Philadelphia, PA (R.C.S., S.T., C.A., T.S., J.M., W.B., G.Z., R.C.G., J.H.G., M.J.G.); Department of Cardiology (M.A.H., G.L.F., T.S.K, Y.D., A.C.G, J.J.R., M.J.G.) and Department Radiology (H.L.), Perelman School of Medicine, University of Pennsylvania, Philadelphia; and Department of Cardiothoracic Surgery, University Medical Center Groningen, University of Groningen, the Netherlands (R.C.S., W.B.). gillespie@email.chop.edu.
University of Pennsylvania · US

Funding

Surgery to Prevent Post Infarction Ventricular RemodelingR01HL063954 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI GORMAN, ROBERT C · 2001 to 2018
$9.8M
Echocardiography to Predict Recurrent IMR After Surgical Mitral Valve ReplacementR01HL103723 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI GORMAN, ROBERT C, HUNG, JUDY W · 2011 to 2020
$5.3M
NHLBI NIH HHS R01 HL063954NHLBI NIH HHS R01 HL103723
6 · The paper itself

Abstract

backgroundPulmonary insufficiency is the nexus of late morbidity and mortality after transannular patch repair of tetralogy of Fallot. This study aimed to establish the feasibility of implantation of the novel Medtronic Harmony transcatheter pulmonary valve (hTPV) and to assess its effect on pulmonary insufficiency and ventricular function in an ovine model of chronic postoperative pulmonary insufficiency. METHODS AND

resultsThirteen sheep underwent baseline cardiac magnetic resonance imaging, surgical pulmonary valvectomy, and transannular patch repair. One month after transannular patch repair, the hTPV was implanted, followed by serial magnetic resonance imaging and computed tomography imaging at 1, 5, and 8 month(s). hTPV implantation was successful in 11 animals (85%). There were 2 procedural deaths related to ventricular fibrillation. Seven animals survived the entire follow-up protocol, 5 with functioning hTPV devices. Two animals had occlusion of hTPV with aneurysm of main pulmonary artery. A strong decline in pulmonary regurgitant fraction was observed after hTPV implantation (40.5% versus 8.3%; P=0.011). Right ventricular end diastolic volume increased by 49.4% after transannular patch repair (62.3-93.1 mL/m

conclusionshTPV implantation is feasible, significantly reduces pulmonary regurgitant fraction, facilitates right ventricular volume improvements, and preserves biventricular function in an ovine model of chronic pulmonary insufficiency. This percutaneous strategy could potentially offer an alternative for standard surgical pulmonary valve replacement in dilated right ventricular outflow tracts, permitting lower risk, nonsurgical pulmonary valve replacement in previously prohibitive anatomies.

Indexed as

cardiac catheterizationcomputed tomographyheart valve prosthesis implantationmagnetic resonance imagingpulmonary valve regurgitationtetralogy of Fallot

Identifiers

PMID27662847
PMCPMC6563325
OpenAlexW2522298428

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.