Commentary: Can We See the Forest for the IVs?: Mendelian Randomization Studies with Multiple Genetic Variants.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

10 citing papers in PubMed.

1. Multiplicative versus additive modelling of causal effects using instrumental variables for survival outcomes - a comparison.Statistical methods in medical research · 2025
   Article
2. Bounding the average causal effect in Mendelian randomisation studies with multiple proposed instruments: An application to prenatal alcohol exposure and attention deficit hyperactivity disorder.Paediatric and perinatal epidemiology · 2023
   Article
3. Nonparametric bounds in two-sample summary-data Mendelian randomization: Some cautionary tales for practice.Statistics in medicine · 2022
   Article
4. Mendelian Randomization: Concepts and Scope.Cold Spring Harbor perspectives in medicine · 2022
   Review
5. Epidemiology, genetic epidemiology and Mendelian randomisation: more need than ever to attend to detail.Human genetics · 2020
   Article
6. The challenging interpretation of instrumental variable estimates under monotonicity.International journal of epidemiology · 2018
   Article
7. Causal null hypotheses of sustained treatment strategies: What can be tested with an instrumental variable?European journal of epidemiology · 2018
   Review
8. Understanding the Assumptions Underlying Instrumental Variable Analyses: a Brief Review of Falsification Strategies and Related Tools.Current epidemiology reports · 2018
   Review
9. Nature as a Trialist?: Deconstructing the Analogy Between Mendelian Randomization and Randomized Trials.Epidemiology (Cambridge, Mass.) · 2017
   Article
10. Instrumental Variable Analyses in Pharmacoepidemiology: What Target Trials Do We Emulate?Current epidemiology reports · 2017
    Review

Corrections and comments

• Comment on
  Sensitivity Analyses for Robust Causal Inference from Mendelian Randomization Analyses with Multiple Genetic Variants.2017

Authors and funding

1 author.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

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