ArticlePloS one
Feasibility of MR-Based Body Composition Analysis in Large Scale Population Studies.
Article in PloS one. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 89 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of Biomarkers to Quantify Liver Pathology in Patients With Presumed Non-Alcoholic Steatohepatitis at Baseline and Following Bariatric Surgery (BARI)
Longitudinal Assessment of Muscle Health in Patients Undergoing Liver Transplantation (LT) for Hepatocellular Carcinoma (HCC)
Adverse Outcomes and Mortality in Liver Transplant
Who cites it
89 citing papers in PubMed, 3 syntheses or guidelines pooled it, 154 citations in OpenAlex.
- A systematic review of automated segmentation of 3D computed-tomography scans for volumetric body composition analysis.Journal of cachexia, sarcopenia and muscle · 2023Pooled it
- Liver, visceral and subcutaneous fat in men and women of South Asian and white European descent: a systematic review and meta-analysis of new and published data.Diabetologia · 2023Pooled it
- Adiposity and risk of prostate cancer death: a prospective analysis in UK Biobank and meta-analysis of published studies.BMC medicine · 2022Pooled it
- Effects of Empagliflozin Treatment on Glycerol-Derived Hepatic Gluconeogenesis in Adults with Obesity: A Randomized Clinical Trial.Obesity (Silver Spring, Md.) · 2020Trial
- Trial
- Integrative Analysis Uncover the Effects and Multi-Omics Features of Thigh Muscle Fat Infiltration.Aging cell · 2026Article
- Genetically Determined Loss-of-Function of the Organic Cation Transporter OCT1 Is Associated with Lower Liver Fat Content in Humans.International journal of molecular sciences · 2026Article
- Opportunistic screening for incident cardiometabolic disease in metabolically healthy non-obese individuals: a prospective cohort study.Cardiovascular diabetology · 2026Article
- A method for tissue-mask supported whole-body image registration in the UK Biobank.Scientific reports · 2026Article
- Multi-organ imaging and genetics show the impact of sleep patterns on the human brain and body.Communications medicine · 2026Article
- Automated volumetric MRI quantification of body fat and skeletal muscle in the UK Biobank: technical validation against expert manual segmentations and comparison with single-slice techniques.Abdominal radiology (New York) · 2026Article
- Reference Methods for Measuring Skeletal Muscle Mass: A Critical Perspective.Journal of cachexia, sarcopenia and muscle · 2026Review
- Age- and BMI-Dependent Psoas and Gluteus Muscle Mass in 27,805 Participants of the Population-Based German National Cohort (NAKO Gesundheitsstudie): A Deep-Learning 3T MRI Study.Diagnostics (Basel, Switzerland) · 2026Article
- MRI-Derived Body Composition and Breast Cancer Risk in Postmenopausal Women: UK Biobank Study.Cancers · 2025Article
- Sex-specific body fat distribution predicts cardiovascular ageing.European heart journal · 2025Article
- Ectopic Fat distribution and adverse muscle composition in South Asians: Findings from the UK biobank.American journal of preventive cardiology · 2025Article
- Sex-specific associations of intrapancreatic fat deposition with incident type 2 diabetes.Communications medicine · 2025Article
- Identification of novel vertebral development factors through UK Biobank candidate gene search and body imaging analysis.Communications biology · 2025Article
- Adiposity, mortality, and disease risk: insights from bioimpedance analysis and magnetic resonance imaging.BMC medicine · 2025Article
- Brain insulin receptor gene network shapes risk for metabolic disease after early-life stress in women.Communications biology · 2025Article
29 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
introductionQuantitative and accurate measurements of fat and muscle in the body are important for prevention and diagnosis of diseases related to obesity and muscle degeneration. Manually segmenting muscle and fat compartments in MR body-images is laborious and time-consuming, hindering implementation in large cohorts. In the present study, the feasibility and success-rate of a Dixon-based MR scan followed by an intensity-normalised, non-rigid, multi-atlas based segmentation was investigated in a cohort of 3,000 subjects. MATERIALS AND
methods3,000 participants in the in-depth phenotyping arm of the UK Biobank imaging study underwent a comprehensive MR examination. All subjects were scanned using a 1.5 T MR-scanner with the dual-echo Dixon Vibe protocol, covering neck to knees. Subjects were scanned with six slabs in supine position, without localizer. Automated body composition analysis was performed using the AMRA Profiler™ system, to segment and quantify visceral adipose tissue (VAT), abdominal subcutaneous adipose tissue (ASAT) and thigh muscles. Technical quality assurance was performed and a standard set of acceptance/rejection criteria was established. Descriptive statistics were calculated for all volume measurements and quality assurance metrics.
resultsOf the 3,000 subjects, 2,995 (99.83%) were analysable for body fat, 2,828 (94.27%) were analysable when body fat and one thigh was included, and 2,775 (92.50%) were fully analysable for body fat and both thigh muscles. Reasons for not being able to analyse datasets were mainly due to missing slabs in the acquisition, or patient positioned so that large parts of the volume was outside of the field-of-view. DISCUSSION AND
conclusionsIn conclusion, this study showed that the rapid UK Biobank MR-protocol was well tolerated by most subjects and sufficiently robust to achieve very high success-rate for body composition analysis. This research has been conducted using the UK Biobank Resource.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.