ReviewCurrent opinion in genetics & development2016
Recent advances in the study of fine-scale population structure in humans.
Review in Current opinion in genetics & development, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed.
- Spatial modelling improves genomic evaluation in Tanzanian smallholder admixed dairy cattle.Genetics, selection, evolution : GSE · 2026Article
- Placental biology links genetic, epigenetic, ancestral, and social determinants to maternal-fetal health inequities.Frontiers in reproductive health · 2026Review
- Comparative Whole Genome Phylogeography Reveals Genetic Distinctiveness of Appalachian Populations of Boreal Songbirds.Evolutionary applications · 2025Article
- Jointly representing long-range genetic similarity and spatially heterogeneous isolation-by-distance.PLoS genetics · 2025Article
- Article
- Social and scientific motivations to move beyond groups in allele frequencies: The TOPMed experience.American journal of human genetics · 2022Review
- How methodological changes have influenced our understanding of population structure in threatened species: insights from tiger populations across India.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- The apportionment of citations: a scientometric analysis of Lewontin 1972.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- The background and legacy of Lewontin's apportionment of human genetic diversity.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Re-situations of scientific knowledge: a case study of a skirmish over clusters vs clines in human population genomics.History and philosophy of the life sciences · 2022Article
- Article
- Leveraging genetic ancestry to study health disparities.American journal of physical anthropology · 2021Article
- Fine-Scale Genetic Structure and Demographic History in the Miyako Islands of the Ryukyu Archipelago.Molecular biology and evolution · 2021Article
- Changes in the fine-scale genetic structure of Finland through the 20th century.PLoS genetics · 2021Article
- Performance of model-based multifactor dimensionality reduction methods for epistasis detection by controlling population structure.BioData mining · 2021Article
- A variant-centric perspective on geographic patterns of human allele frequency variation.eLife · 2020Article
- Genetic Landscapes Reveal How Human Genetic Diversity Aligns with Geography.Molecular biology and evolution · 2020Article
- OPENMENDEL: a cooperative programming project for statistical genetics.Human genetics · 2020Review
- Exploring Population Structure with Admixture Models and Principal Component Analysis.Methods in molecular biology (Clifton, N.J.) · 2020Article
- Network-based hierarchical population structure analysis for large genomic data sets.Genome research · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Empowered by modern genotyping and large samples, population structure can be accurately described and quantified even when it only explains a fraction of a percent of total genetic variance. This is especially relevant and interesting for humans, where fine-scale population structure can both confound disease-mapping studies and reveal the history of migration and divergence that shaped our species' diversity. Here we review notable recent advances in the detection, use, and understanding of population structure. Our work addresses multiple areas where substantial progress is being made: improved statistics and models for better capturing differentiation, admixture, and the spatial distribution of variation; computational speed-ups that allow methods to scale to modern data; and advances in haplotypic modeling that have wide ranging consequences for the analysis of population structure. We conclude by outlining four important open challenges: the limitations of discrete population models, uncertainty in individual origins, the incorporation of both fine-scale structure and ancient DNA in parametric models, and the development of efficient computational tools, particularly for haplotype-based methods.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.