ArticleHealth security
Comprehensive Laboratory Evaluation of a Highly Specific Lateral Flow Assay for the Presumptive Identification of Bacillus anthracis Spores in Suspicious White Powders and Environmental Samples.
Article in Health security. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Geometric Optimization of GMR Biosensors with Trapezoidal Magnetic Flux Concentrators for DetectingSensors (Basel, Switzerland) · 2026Article
- Electrochemical Immunodetection ofSensors (Basel, Switzerland) · 2025Article
- Biosensors and Bioassays for the Medical Detection ofCurrent medicinal chemistry · 2025Review
- The use of lateral flow immunoassays for the detection of fentanyl in seized drug samples and postmortem urine.Journal of forensic sciences · 2021Article
- Rapid Microscopic Detection ofMicroorganisms · 2020Article
- Rapid and Sensitive Multiplex Assay for the Detection ofPathogens (Basel, Switzerland) · 2020Article
- Evaluation of a lateral flow immunoassay for the detection of the synthetic opioid fentanyl.Forensic science international · 2019Article
- Botulinum Neurotoxin Detection Methods for Public Health Response and Surveillance.Frontiers in bioengineering and biotechnology · 2018Review
- Primary Blast-Induced Changes in Akt and GSKFrontiers in neurology · 2017Article
- Comprehensive Laboratory Evaluation of a Specific Lateral Flow Assay for the Presumptive Identification ofHealth securityArticle
- Article
- Rapid Presumptive Identification ofHealth securityArticle
Corrections and comments
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Authors and funding
22 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We conducted a comprehensive, multiphase laboratory evaluation of the Anthrax BioThreat Alert(®) test strip, a lateral flow immunoassay (LFA) for the rapid detection of Bacillus anthracis spores. The study, conducted at 2 sites, evaluated this assay for the detection of spores from the Ames and Sterne strains of B. anthracis, as well as those from an additional 22 strains. Phylogenetic near neighbors, environmental background organisms, white powders, and environmental samples were also tested. The Anthrax LFA demonstrated a limit of detection of about 10(6) spores/mL (ca. 1.5 × 10(5) spores/assay). In this study, overall sensitivity of the LFA was 99.3%, and the specificity was 98.6%. The results indicated that the specificity, sensitivity, limit of detection, dynamic range, and repeatability of the assay support its use in the field for the purpose of qualitatively evaluating suspicious white powders and environmental samples for the presumptive presence of B. anthracis spores.
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Registered trials
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