Trial reportAddiction (Abingdon, England)2017
Patient-centered methadone treatment: a randomized clinical trial.
Trial report in Addiction (Abingdon, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04650386 (Enhancing Office-based Buprenorphine Treatment), which is not on this map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Enhancing Office-based Buprenorphine Treatment: An Adaptive Psychosocial Approach
Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Diversity inclusion in United States opioid pharmacological treatment trials: A systematic review.Experimental and clinical psychopharmacology · 2021Pooled it
- Psychosocial interventions to reduce alcohol consumption in concurrent problem alcohol and illicit drug users.The Cochrane database of systematic reviews · 2018Pooled it
- Randomized trial of methadone treatment of arrestees: 24-month post-release outcomes.Drug and alcohol dependence · 2021Trial
- An intervention trial targeting methadone maintenance treatment providers to improve clients' treatment retention in China.Drug and alcohol dependence · 2019Trial
- Re-engineering methadone-Cost-effectiveness analysis of a patient-centered approach to methadone treatment.Journal of substance abuse treatment · 2018Trial
- Slow-Release Oral Morphine vs Methadone for Opioid Use Disorder in the Fentanyl Era.JAMA network open · 2026Article
- Quality of life measures in treatment for active substance misuse: a scoping review.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025Article
- The Development of a Patient-Centered Digital Health Care Technology for Young Adults in Opioid Use Disorder Treatment: Qualitative Study.JMIR formative research · 2025Article
- Overcoming barriers to traditional care delivery and pharmacy challenges: a qualitative study of buprenorphine, telehealth, and a digital therapeutic for opioid use disorder.Substance abuse treatment, prevention, and policy · 2025Article
- Extraction of Substance Use Information From Clinical Notes: Generative Pretrained Transformer-Based Investigation.JMIR medical informatics · 2024Article
- Typology of laws restricting access to methadone treatment in the United States: A latent class analysis.The International journal on drug policy · 2023Article
- Deimplementation in the provision of opioid agonist treatment to achieve equity of care for people engaged in treatment: a qualitative study.Implementation science : IS · 2023Article
- What's in a Name? Terminology Preferences Among Patients Receiving Methadone Treatment.Journal of general internal medicine · 2023Article
- Evaluation of real-world outcomes associated with use of a prescription digital therapeutic to treat substance use disorders.The American journal on addictions · 2023Article
- Readiness to Provide Medications for Addiction Treatment in HIV Clinics: A Multisite Mixed-Methods Formative Evaluation.Journal of acquired immune deficiency syndromes (1999) · 2021Article
- Re-thinking patient stability for methadone in opioid treatment programs during a global pandemic: Provider perspectives.Journal of substance abuse treatment · 2021Article
- A qualitative investigation of addiction counselors' perceptions and experiences implementing an open-access model for treating opioid use disorder.Journal of substance abuse treatment · 2021Article
- Creating an ethical culture to support recovery from substance use disorders.Journal of medical ethics · 2020Article
- Comparative Effectiveness of Different Treatment Pathways for Opioid Use Disorder.JAMA network open · 2020Article
- Building healthcare provider relationships for patient-centered care: A qualitative study of the experiences of people receiving injectable opioid agonist treatment.Substance abuse treatment, prevention, and policy · 2020Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
BACKGROUND AND
aimsMethadone patients who discontinue treatment are at high risk of relapse, yet a substantial proportion discontinue treatment within the first year. We investigated whether a patient-centered approach to methadone treatment improved participant outcomes at 12 months following admission, compared with methadone treatment-as-usual.
designTwo-arm open-label randomized trial.
settingTwo methadone treatment programs (MTPs) in Baltimore, MD, USA.
participantsThree hundred newly admitted MTP patients were enrolled between 13 September 2011 and 26 March 2014. Their mean age was 42.7 years [standard deviation (SD) = 10.1] and 59% were males.
interventionNewly admitted MTP patients were assigned randomly to either patient-centered methadone treatment (PCM; n = 149), which modified the MTP's rules (e.g. counseling attendance was optional), and counselor roles (e.g. counselors were not responsible for enforcing clinic rules) or treatment-as-usual (TAU; n = 151). MEASUREMENTS: The primary outcome was opioid-positive urine test at 12-month follow-up. Other 12-month outcomes included days of heroin and cocaine use, cocaine-positive urine tests, meeting DSM-IV opioid and cocaine dependence diagnostic criteria, HIV risk behavior and quality of life and retention in treatment.
findingsThere was no significant difference between PCM and TAU conditions in opioid-positive urine screens at 12 months [adjusted odds ratio = 0.98; 95% confidence interval (CI) = 0.61, 1.56]. There were also no significant differences in any of the secondary outcome measures (all Ps > 0.05) except Quality of Life Global Score (P = 0.04; 95% CI = 0.01, 0.45). There were no significant differences between conditions in the number of individual or group counseling sessions attended. (Ps > 0.05).
conclusionsPatient-centered methadone treatment (with optional counseling and the counselor not serving as the treatment program disciplinarian) does not appear to be more effective than methadone treatment-as-usual.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.