Evidence map›Paper›PMID 27661468›Full record

ReviewRNA biology2017

The Cajal body and the nucleolus: "In a relationship" or "It's complicated"?

Laura Trinkle-Mulcahy, Judith E Sleeman

Abstract readReview
In one paragraph

Review in RNA biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed.

  1. Article
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  3. Female Aging Affects Coilin Pattern in Mouse Cumulus Cells.Journal of developmental biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Laura Trinkle-Mulcahya Department of Cellular and Molecular Medicine , Ottawa Institute of Systems Biology, University of Ottawa , Ottawa , ON , Canada.ORCID 0000-0002-7619-2841
Judith E Sleemanb BSRC Complex, School of Biology, University of St Andrews , UK.ORCID 0000-0003-0345-6508

Funding

Wellcome Trust 105621/Z/14/Z
6 · The paper itself

Abstract

From their initial identification as 'nucleolar accessory bodies' more than a century ago, the relationship between Cajal bodies and nucleoli has been a subject of interest and controversy. In this review, we seek to place recent developments in the understanding of the physical and functional relationships between the 2 structures in the context of historical observations. Biophysical models of nuclear body formation, the molecular nature of CB/nucleolus interactions and the increasing list of joint roles for CBs and nucleoli, predominantly in assembling ribonucleoprotein (RNP) complexes, are discussed.

Indexed as

AnimalsCell NucleolusCoiled BodiesHumansMutationNuclear ProteinsProtein BindingRibonucleoproteins, Small NuclearRNA InterferenceRNA Processing, Post-TranscriptionalRNA, Small NuclearTelomere HomeostasisNuclear Proteinsp80-coilinRibonucleoproteins, Small NuclearRNA, Small NuclearCajal bodycoilinnon-coding RNAsnuclear bodiesnuclear structurenucleolusphase separationsnoRNPssnRNPstelomerase

Identifiers

PMID27661468
PMCPMC5519233

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.