SynthesisOncotarget2017
Outcomes in adult critically ill cancer patients with and without neutropenia: a systematic review and meta-analysis of the Groupe de Recherche en Réanimation Respiratoire du patient d'Onco-Hématologie (GRRR-OH).
Synthesis in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Changes in critically ill cancer patients' short-term outcome over the last decades: results of systematic review with meta-analysis on individual data.Intensive care medicine · 2019Pooled it
- Influence of neutropenia on mortality of critically ill cancer patients: results of a meta-analysis on individual data.Critical care (London, England) · 2018Pooled it
- Intensivist and Hematologist Perceptions of Prognosis of Critically Ill Patients with Hematologic Malignancies.Journal of intensive care medicine · 2026Article
- Postoperative complications in patients with chemotherapy-induced acute myeloid leukemia (Review).Oncology letters · 2026Review
- Impact of Neutropenia on Clinical Outcomes in Critically Ill Patients with Acute Respiratory Failure.Pulmonary therapy · 2025Article
- When and for Whom Does Intensive Care Unit Admission Change the Prognosis in Oncology?-A Scoping Review.Cancers · 2025Review
- Patients admitted in the intensive care unit after solid organ or bone marrow transplantation: Retrospective cohort study.World journal of transplantation · 2025Article
- Prognostic Impact of Neutropenia Recovery and G-CSF Use in Onco-Hematological Neutropenic Patients Admitted to Intensive Care Unit for Acute Respiratory Failure: A Retrospective, Real World Analysis.Advances in therapy · 2025Article
- Septic shock in the immunocompromised cancer patient: a narrative review.Critical care (London, England) · 2024Review
- Patients with cancer and sepsis trials: an unfair representation?Clinical medicine (London, England) · 2023Article
- Prognostic factors in oncological patients with solid tumours requiring intensive care unit admission.Oncology letters · 2023Article
- Safety and Effectiveness of Intensive Treatments Administered Outside the Intensive Care Unit to Hematological Critically Ill Patients: An Intensive Care without Walls Trial.Journal of clinical medicine · 2023Article
- Abdominal emergency surgery in patients with hematological malignancies: a retrospective single-center analysis.World journal of emergency surgery : WJES · 2023Article
- Prognostic factors for multi-organ dysfunction in pediatric oncology patients admitted to the pediatric intensive care unit.Frontiers in oncology · 2023Article
- Prognostic Impact of Neutropenia in Cancer Patients with Septic Shock: A 2009-2017 Nationwide Cohort Study.Cancers · 2022Article
- Article
- A 12-year study evaluating the outcomes and predictors of mortality in critically ill cancer patients admitted with septic shock.BMC cancer · 2021Article
- The Association of Laboratory Test Abnormalities With Mortality Risk in Pediatric Intensive Care.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2021Article
- Outcomes of Sepsis and Septic Shock in Cancer Patients: Focus on Lactate.Frontiers in medicine · 2021Article
- Acute respiratory failure in immunocompromised patients: outcome and clinical features according to neutropenia status.Annals of intensive care · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWhether neutropenia has an impact on the mortality of critically ill cancer patients remains controversial, yet it is widely used as an admission criterion and prognostic factor.
methodsSystematic review and meta-analysis. Studies on adult cancer patients and intensive care units were searched on PubMed and Cochrane databases (2005-2015). Summary estimates of mortality risk differences were calculated using the random-effects model.
resultsAmong the 1,528 citations identified, 38 studies reporting on 6,054 patients (2,097 neutropenic patients) were included. Median mortality across the studies was 54% [45-64], with unadjusted mortality in neutropenic and non-neutropenic critically ill patients of 60% [53-74] and 47% [41-68], respectively. Overall, neutropenia was associated with a 10% increased mortality risk (6%-14%; I² = 50%). The admission period was not associated with how neutropenia affected mortality. Mortality significantly dropped throughout the study decade [-11% (-13.5 to -8.4)]. This mortality drop was observed in non-neutropenic patients [-12.1% (-15.2 to -9.0)] but not in neutropenic patients [-3.8% (-8.1 to +5.6)].Sensitivity analyses disclosed no differences in underlying malignancy, mechanical ventilation use, or Granulocyte-colony stimulating factor use. Seven studies allowed the adjustment of severity results (1,350 patients). Although pooled risk difference estimates were similar to non-adjusted results, there was no significant impact of neutropenia on mortality (risk difference of mortality, 9%; 95% CI, -15 to +33).
conclusionAlthough the unadjusted mortality of neutropenic patients was 11% higher, this effect disappeared when adjusted for severity. Therefore, when cancer patients become critically ill, neutropenia cannot be considered as a decision-making criterion.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.