ReviewAmerican journal of hypertension2017
Blood Pressure and Mortality in Long-Term Hemodialysis-Time to Move Forward.
Review in American journal of hypertension, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Peridialysis BP levels and risk of all-cause mortality: a dose-response meta-analysis.Journal of human hypertension · 2019Pooled it
- Efficacy of a Web-Based Home Blood Pressure Monitoring Program in Improving Predialysis Blood Pressure Control Among Patients Undergoing Hemodialysis: Randomized Controlled Trial.JMIR mHealth and uHealth · 2024Trial
- Nighttime Systolic Blood Pressure and Cardiovascular and All-Cause Mortality in Peritoneal Dialysis Patients: A Single-Center Prospective Cohort Study.Journal of clinical medicine · 2026Article
- Comparative associations of home and dialysis-unit blood pressure with left ventricular mass and arterial stiffness in maintenance hemodialysis patients.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Machine Learning-Based Prediction of Life-Threatening Complications During Hemodialysis in Hospitalized Patients With Poor General Conditions.Artificial organs · 2026Article
- Post-dialysis blood pressure: inaccuracy or lack of standardization?Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Observational
- How to demonstrate the prognostic impact of interdialytic home blood pressure variability in dialytic patients.Clinical cardiology · 2024Article
- Mortality in hemodialysis patients in Ethiopia: a retrospective follow-up study in three centers.BMC nephrology · 2023Article
- Associations between long-term blood pressure trajectory and all-cause and CVD mortality among old people in China.Frontiers in cardiovascular medicine · 2023Article
- Hypertension in Dialysis Patients: Diagnostic Approaches and Evaluation of Epidemiology.Diagnostics (Basel, Switzerland) · 2022Review
- Clinical practice guideline exercise and lifestyle in chronic kidney disease.BMC nephrology · 2022Article
- Risks associated with continuation of potentially inappropriate antihypertensive medications in older adults receiving hemodialysis.BMC nephrology · 2021Article
- The Relation of Clinic and Ambulatory BP with the Risk of Cardiovascular Events and All-Cause Mortality among Patients on Peritoneal Dialysis.Journal of clinical medicine · 2021Article
- Brazilian Guidelines of Hypertension - 2020.Arquivos brasileiros de cardiologia · 2021Article
- Association of all-cause mortality with pre-dialysis systolic blood pressure and its peridialytic change in chronic hemodialysis patients.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2020Observational
- Cardiorenal protection in advanced chronic kidney disease: research highlights from landmark papers published in Nephrology Dialysis Transplantation during 2018.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2020Article
- Systolic and diastolic hypertension among patients on hemodialysis: Musings on volume overload, arterial stiffness, and erythropoietin.Seminars in dialysis · 2019Review
- Blood pressure control in conventional hemodialysis.Seminars in dialysis · 2018Review
- Blood pressure in hemodialysis: targets?Current opinion in nephrology and hypertension · 2017Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Contrary to the direct, graded, and causal relationship of hypertension with cardiovascular outcomes in the general population, among dialysis patients, blood pressure (BP) recorded either predialysis or postdialysis displays a U-shaped curve with mortality. This paradoxical phenomenon of lower BP or a decline in BP over time being associated with increased mortality and higher BP being associated with a lower mortality is described as "reverse" epidemiology of hypertension, raising substantial controversy on whether BP lowering causes harms or benefits among dialysis patients. Unlike the inverse relationship of peridialytic BP with mortality, elevated BP recorded outside of dialysis is directly associated with poor long-term outcomes. Apart from the timing and technique of BP measurement, the U-shaped association of BP with mortality is also modified when accounting for factors related to patient's clinical characteristics and level of illness, dialysis practices, and patterns as well as factors related to the methodology of survival analysis. Most importantly, deliberate BP lowering with antihypertensive drugs is associated with reduced cardiovascular morbidity and mortality. In this review, we explore the complex association of peridialytic, intradialytic, and interdialytic BP with outcomes among dialysis patients. We conclude with recommendations for a wider use of out-of-dialysis BP monitoring as a tool to better evaluate the cardiovascular risk and optimize the management of hypertension in this high-risk population. Rather than more cohort studies, we call for randomized trials to test the level of BP in dialysis patients that is optimal for cardiovascular outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.