ArticleOncotarget2016
Systematically characterizing dysfunctional long intergenic non-coding RNAs in multiple brain regions of major psychosis.
Article in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 4 of them syntheses that pooled it.
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Who cites it
30 citing papers in PubMed, 4 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- The Association and Prognostic Implications of Long Non-Coding RNAs in Major Psychiatric Disorders, Alzheimer's Diseases and Parkinson's Diseases: A Systematic Review.International journal of molecular sciences · 2024Pooled it
- The impact of sex on gene expression in the brain of schizophrenic patients: a systematic review and meta-analysis of transcriptomic studies.Biology of sex differences · 2024Pooled it
- A Review on the Expression Pattern of Non-coding RNAs in Patients With Schizophrenia: With a Special Focus on Peripheral Blood as a Source of Expression Analysis.Frontiers in psychiatry · 2021Pooled it
- Postmortem evidence of brain inflammatory markers in bipolar disorder: a systematic review.Molecular psychiatry · 2020Pooled it
- The role ofEpigenetics · 2026Review
- Altered expression of LINC03091 and LINC03090 LncRNAs in bipolar disorder: a case-control study.Scientific reports · 2025Article
- Alteration in CaMolecular biology reports · 2025Article
- Deciphering transcriptomic signatures in schizophrenia, bipolar disorder, and major depressive disorder.Frontiers in psychiatry · 2025Article
- Long non-coding RNAs expression and regulation across different brain regions in primates.Scientific data · 2024Article
- Comparative Transcriptomics Data Profiling Reveals E2F Targets as an Important Biological Pathway Overexpressed in Intellectual Disability Disorder.Bioinformatics and biology insights · 2024Article
- DC vaccines loaded with glioma cells killed by photodynamic therapy induce Th17 anti-tumor immunity and provide a four-gene signature for glioma prognosis.Cell death & disease · 2022Article
- Shared mechanisms across the major psychiatric and neurodegenerative diseases.Nature communications · 2022Article
- Amygdala and anterior cingulate transcriptomes from individuals with bipolar disorder reveal downregulated neuroimmune and synaptic pathways.Nature neuroscience · 2022Article
- The emerging role of long non-coding RNAs in schizophrenia.Frontiers in psychiatry · 2022Review
- Association study of a genetic variant in the long intergenic noncoding RNA (linc01080) with schizophrenia in Han Chinese.BMC psychiatry · 2021Article
- Expression of BDNF-Associated lncRNAs in Treatment-Resistant Schizophrenia Patients.Journal of molecular neuroscience : MN · 2021Article
- Regulatory role of long non coding RNAs (lncRNAs) in neurological disorders: From novel biomarkers to promising therapeutic strategies.Asian journal of pharmaceutical sciences · 2021Review
- A Comprehensive Review on the Role of Non-Coding RNAs in the Pathophysiology of Bipolar Disorder.International journal of molecular sciences · 2021Review
- Selective time-dependent changes in activity and cell-specific gene expression in human postmortem brain.Scientific reports · 2021Article
- Epigenomic Dysregulation in Schizophrenia: In Search of Disease Etiology and Biomarkers.Cells · 2020Review
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Schizophrenia (SZ) and bipolar disorder (BD) are severe neuropsychiatric disorders with serious impact on patients, together termed "major psychosis". Recently, long intergenic non-coding RNAs (lincRNAs) were reported to play important roles in mental diseases. However, little was known about their molecular mechanism in pathogenesis of SZ and BD. Here, we performed RNA sequencing on 82 post-mortem brain tissues from three brain regions (orbitofrontal cortex (BA11), anterior cingulate cortex (BA24) and dorsolateral prefrontal cortex (BA9)) of patients with SZ and BD and control subjects, generating over one billion reads. We characterized lincRNA transcriptome in the three brain regions and identified 20 differentially expressed lincRNAs (DELincRNAs) in BA11 for BD, 34 and 1 in BA24 and BA9 for SZ, respectively. Our results showed that these DELincRNAs exhibited brain region-specific patterns. Applying weighted gene co-expression network analysis, we revealed that DELincRNAs together with other genes can function as modules to perform different functions in different brain regions, such as immune system development in BA24 and oligodendrocyte differentiation in BA9. Additionally, we found that DNA methylation alteration could partly explain the dysregulation of lincRNAs, some of which could function as enhancers in the pathogenesis of major psychosis. Together, we performed systematical characterization of dysfunctional lincRNAs in multiple brain regions of major psychosis, which provided a valuable resource to understand their roles in SZ and BD pathology and helped to discover novel biomarkers.
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