Evidence map›Paper›PMID 27660721›Full record

ArticleIranian Red Crescent medical journal2016

Comparison Between the Cassia Fistula`s Emulsion With Polyethylene Glycol (PEG4000) in the Pediatric Functional Constipation: A Randomized Clinical Trial.

Mohammad Reza Esmaeilidooki, Seyyed Ali Mozaffarpur, Mohaddese Mirzapour, Hoda Shirafkan, Mohammad Kamalinejad, Ali Bijani

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Iranian Red Crescent medical journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 6 pooled it
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 6 syntheses or guidelines pooled it, 23 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Traditional, complementary and alternative medicine in children constipation: a systematic review.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2019
    Pooled it
  6. Pooled it
  7. Review
  8. Review
  9. Review
  10. Article
  11. Comparative Evaluation between the LaxaPlus BarijJournal of research in pharmacy practice
    Article
  12. The efficacy ofAvicenna journal of phytomedicine
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Mohammad Reza EsmaeilidookiDepartment of Pediatrics, Non-Communicable Pediatric Disease Research Center, Babol University of Medical Sciences, Babol, IR Iran.
Seyyed Ali MozaffarpurTraditional Medicine and History of Medical Sciences Research Center, Babol University of Medical Sciences, Babol, IR Iran; Department of Traditional Iranian Medicine, Faculty of Traditional Iranian Medicine, Babol University of Medical Sciences, Babol, IR Iran.
Mohaddese MirzapourTraditional Medicine and History of Medical Sciences Research Center, Babol University of Medical Sciences, Babol, IR Iran; Department of Traditional Iranian Medicine, Faculty of Traditional Iranian Medicine, Babol University of Medical Sciences, Babol, IR Iran.
Hoda ShirafkanDepartment of Traditional Iranian Medicine, Faculty of Traditional Iranian Medicine, Babol University of Medical Sciences, Babol, IR Iran; Departments of Statistics and Biostatistics, Mazandaran University of Medical Sciences, Sari, IR Iran.
Mohammad KamalinejadSchool of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.
Ali BijaniSocial Health Research Center, Babol University of Medical Sciences, Babol, IR Iran.
Babol University of Medical Sciences · IRMazandaran University of Medical Sciences · IRShahid Beheshti University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere are few effective drugs for pediatric functional constipation (FC).

objectivesComparing the effectiveness of Cassia fistula's emulsion (CFE) with Polyethylene glycol (PEG4000) in FC; and evaluation of safety of both drugs in the treatment of FC. MATERIALS AND

methodsA randomized open label, prospective, controlled, parallel-group clinical trial was carried on 109 children (M/F: 63/46; mean age ± SD: 59.7 ± 28.8 months) in Amirkola children's hospital, Babol, Iran. The inclusion criteria were based on diagnosis of FC according to the Rome III criteria and age range between 2 - 15 years. They received CFE or PEG randomly for 4 weeks. Frequencies of defecation, severity of pain, consistency of stool, fecal incontinence and retentive posturing were compared between the two groups and with baselines. Children were counted as improved when they exited from Rome III criteria of FC.

resultsFifty seven patients were assigned to receive PEG and 52 patients received CFE. After 4weeks of medication, 86.5% of children in CFE group and 77.1% in PEG group (RR = 1.121, CI95%:0.939 - 1.338) exited from the criteria of FC. All measurable criteria improved in both groups without any significant difference, except in the frequency of defecation that in CFE group (10.96 ± 5.7) was significantly more than PEG group (6.9 ± 3.5) (P < 0.0001). Compliances of PEG were significantly better in the 2 first weeks (P = 0.002, 0.008) but not in third and fourth week (P = 0.061, 0.062). None of these two drugs cause clinically significant side effects.

conclusionsCFE can be as effective as PEG in the 4-weeks treatment of children with FC.

Indexed as

Cassia fistulaChildClinical TrialConstipationPersian MedicinePolyethylene Glycols

Identifiers

PMID27660721
PMCPMC5027133
OpenAlexW2389074072

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.