Evidence map›Paper›PMID 27660666›Full record

ArticleClinical epigenetics2016

Alexander Semaan, Anne van Ellen, Sebastian Meller, Dominik Bergheim, Vittorio Branchi, Philipp Lingohr, Diane Goltz, Jörg C Kalff, Glen Kristiansen, Hanno Matthaei and 2 more

Open access · goldAbstract read
In one paragraph

Article in Clinical epigenetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 1 pooled it
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.

  1. Pooled it
  2. Epigenetics · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Current Status and Future Perspectives of Molecular Residual Disease Testing in Genitourinary Cancers.International journal of urology : official journal of the Japanese Urological Association · 2025
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Circulating Methylated SEPT9 DNA Analyses to Predict Recurrence Risk and Adjuvant Chemotherapy Benefit in Stage II to III Colorectal Cancer.Medical science monitor : international medical journal of experimental and clinical research · 2022
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Alexander Semaan *Department of General, Visceral, Thoracic and Vascular Surgery, University of Bonn, Sigmund-Freud-Straße 25, 53127 Bonn, Germany.ORCID 0000-0001-5424-3217
Anne van Ellen *Institute of Pathology, University of Bonn, Sigmund-Freud-Straße 25, 53127 Bonn, Germany.
Sebastian MellerInstitute of Pathology, University of Bonn, Sigmund-Freud-Straße 25, 53127 Bonn, Germany.
Dominik BergheimInstitute of Pathology, University of Bonn, Sigmund-Freud-Straße 25, 53127 Bonn, Germany.
Vittorio BranchiDepartment of General, Visceral, Thoracic and Vascular Surgery, University of Bonn, Sigmund-Freud-Straße 25, 53127 Bonn, Germany.
Philipp LingohrDepartment of General, Visceral, Thoracic and Vascular Surgery, University of Bonn, Sigmund-Freud-Straße 25, 53127 Bonn, Germany.
Diane GoltzInstitute of Pathology, University of Bonn, Sigmund-Freud-Straße 25, 53127 Bonn, Germany.
Jörg C KalffDepartment of General, Visceral, Thoracic and Vascular Surgery, University of Bonn, Sigmund-Freud-Straße 25, 53127 Bonn, Germany.
Glen KristiansenInstitute of Pathology, University of Bonn, Sigmund-Freud-Straße 25, 53127 Bonn, Germany.
Hanno MatthaeiDepartment of General, Visceral, Thoracic and Vascular Surgery, University of Bonn, Sigmund-Freud-Straße 25, 53127 Bonn, Germany.
Dimitrios PantelisDepartment of General, Visceral, Thoracic and Vascular Surgery, University of Bonn, Sigmund-Freud-Straße 25, 53127 Bonn, Germany.
Dimo DietrichInstitute of Pathology, University of Bonn, Sigmund-Freud-Straße 25, 53127 Bonn, Germany.
University of Bonn · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundColorectal cancer (CRC) appear to arise from precursor lesions in a well-characterized adenoma-carcinoma sequence. Significant efforts have been invested to develop biomarkers that identify early adenocarcinomas and adenomas with high-grade dysplasia, since these are believed to harbor a particularly high risk for malignant transition and thus require resection. Promoter methylation of

resultsAssessment of promoter methylation of

conclusions

Indexed as

DNA MethylationAdenocarcinomaAdenomaAdultAgedAged, 80 and overColorectal NeoplasmsDiagnosis, DifferentialEarly Detection of CancerEpigenesis, GeneticFemaleHomeodomain ProteinsHumansMaleMicrosatellite InstabilityMiddle AgedHomeodomain ProteinsSEPTIN9 protein, humanSeptinsSHOX2 protein, humanAdenomasAmplificationColorectal cancerMethylationSEPT9SHOX2

Identifiers

PMID27660666
PMCPMC5028994
OpenAlexW2522622119

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.