ArticleNeuropsychiatric disease and treatment2016
Late life bipolar disorder evolving into frontotemporal dementia mimic.
Article in Neuropsychiatric disease and treatment, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Bipolar Disorder and Manic-Like Symptoms in Alzheimer's, Vascular and Frontotemporal Dementia: A Systematic Review.Current neuropharmacology · 2023Pooled it
- Phenocopy syndrome of behavioral variant frontotemporal dementia: a systematic review.Alzheimer's research & therapy · 2019Pooled it
- The spectrum of bipolar disorder in older adults.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Behavioral variant frontotemporal dementia in patients with primary psychiatric disorder: A magnetic resonance imaging study.Brain and behavior · 2023Article
- How to differentiate behavioral variant frontotemporal dementia from primary psychiatric disorders: practical aspects for the clinician.Arquivos de neuro-psiquiatria · 2022Article
- Exploring Signatures of Neurodegeneration in Early-Onset Older-Age Bipolar Disorder and Behavioral Variant Frontotemporal Dementia.Frontiers in neurology · 2021Article
- Frontotemporal Dementia and Late-Onset Bipolar Disorder: The Many Directions of a Busy Road.Frontiers in psychiatry · 2021Review
- Bipolar Disorder Among Patients Diagnosed With Frontotemporal Dementia.The Journal of neuropsychiatry and clinical neurosciences · 2020Review
- A review on shared clinical and molecular mechanisms between bipolar disorder and frontotemporal dementia.Progress in neuro-psychopharmacology & biological psychiatry · 2019Review
- Qualitative Assessment of Longitudinal Changes in Phenocopy Frontotemporal Dementia.Frontiers in neurology · 2019Article
- Frontotemporal Lobe Degeneration as Origin of Scans Without Evidence of Dopaminergic Deficit.Frontiers in neurology · 2018Article
- Manic behavior and asymmetric right frontotemporal dementia from a novel progranulin mutation.Neuropsychiatric disease and treatment · 2018Article
- Update on the Epidemiology, Diagnosis, and Treatment of Mania in Older-Age Bipolar Disorder.Current psychiatry reports · 2017Review
- An Algorithm to Characterize a Dementia Population by Disease Subtype.Alzheimer disease and associated disordersArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesAlthough bipolar disorder has been understood classically as a cyclic disease with full recovery between mood episodes, in the last decade, evidence has accumulated supporting progressive features. The clinical picture of advanced or end-stage bipolar disorder is heterogeneous with possible deficits in cognition and behavior, as illustrated by our case series. CASES: From our neuropsychiatric outpatient clinic, we describe four cases with bipolar disorder gradually developing a clinical syndrome, including apathy, disinhibition, loss of empathy, stereotypical behavior, and compulsiveness, fulfilling the criteria for possible behavioral variant frontotemporal dementia. All cases were diagnosed with bipolar 1 disorder at least 10 years before the onset of the current symptoms, which were not due to recent mood episodes or switches of medication. In all cases, 3-7 years of follow-up yielded no progression. Repeated neuroimaging was within normal limits. Cerebrospinal fluid biomarker studies were not supportive of underlying neurodegenerative pathology. C9orf72 mutation status was negative in all cases.
conclusionSymptoms fitting the criteria for possible behavioral variant frontotemporal dementia may be present in end-stage of bipolar disorder. An alternative neurodegenerative nature seems unlikely based on repeated normal neuroimaging and the absence of clinical progression. Functional involvement of the frontal-subcortical networks might play a role.
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