ArticleCirculation research2016
Nicotine Mediates CD161a+ Renal Macrophage Infiltration and Premature Hypertension in the Spontaneously Hypertensive Rat.
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Article in Circulation research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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34 citing papers in PubMed, 43 citations in OpenAlex.
- Expression of adrenergic and cholinergic receptors on peripheral blood leucocytes of adolescents with primary hypertension.Journal of human hypertension · 2026Article
- Protective Effects of Teucrium Polium Leaf Ethanolic Extract Against Nicotine-Induced Nephrotoxicity in Mice.Physiological research · 2025Article
- Association between circulatory complement activation and hypertensive renal damage: a case-control study.Renal failure · 2024Article
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- Differential changes in end organ immune cells and inflammation in salt-sensitive hypertension: effects of increasing M2 macrophages.Clinical science (London, England : 1979) · 2024Article
- Akkermansia muciniphila extracellular vesicles have a protective effect against hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Inflammation Resolution in the Cardiovascular System: Arterial Hypertension, Atherosclerosis, and Ischemic Heart Disease.Antioxidants & redox signaling · 2024Review
- High mobility group box 1 (HMGB1) mediates nicotine-induced podocyte injury.Frontiers in pharmacology · 2024Article
- A new immune disease: systemic hypertension.Clinical kidney journal · 2023Review
- Xenobiotics Delivered by Electronic Nicotine Delivery Systems: Potential Cellular and Molecular Mechanisms on the Pathogenesis of Chronic Kidney Disease.International journal of molecular sciences · 2022Review
- Hypertension induces gonadal macrophage imbalance, inflammation, lymphangiogenesis, and dysfunction.Clinical science (London, England : 1979) · 2022Article
- The potential role of complement alternative pathway activation in hypertensive renal damage.Experimental biology and medicine (Maywood, N.J.) · 2022Article
- Continuous Positive Linear Association between the Monocyte to High-Density Lipoprotein Cholesterol Ratio and Hypertension: A Cross-Sectional Study.International journal of hypertension · 2022Article
- Four evolving concepts in molecular and clinical autonomic research.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2021Article
- Innate Immune Cells and Hypertension: Neutrophils and Neutrophil Extracellular Traps (NETs).Comprehensive Physiology · 2021Review
- The Application of Functional Magnetic Resonance Imaging in Type 2 Diabetes Rats With Contrast-Induced Acute Kidney Injury and the Associated Innate Immune Response.Frontiers in physiology · 2021Article
- Gamma-aminobutyric acid-salt attenuated high cholesterol/high salt diet induced hypertension in mice.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2021Article
- Transfer of Th17 from Adult Spontaneous Hypertensive Rats Accelerates Development of Hypertension in Juvenile Spontaneous Hypertensive Rats.BioMed research international · 2021Article
- [High-salt exposure induces macrophage polarization to promote proliferation and phenotypic transformation of co-cultured renal fibroblasts].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2020Article
- Is nicotine exposure linked to cardiopulmonary vulnerability to COVID-19 in the general population?The FEBS journal · 2020Review
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Authors and funding
7 authors at 1 institution in 1 country.
Sailesh C HarwaniFrom the Department of Internal Medicine (S.C.H., J.R., F.S.S., Z.K.B., M.W.C., F.M.A.), Departments of Molecular Physiology and Biophysics (M.W.C., F.M.A.), and Veterans Affairs Medical Center (F.S.S., Z.K.B., M.W.C.), Iowa City; and Department of Pathology (D.K.M.), Inflammation Program, Department of Internal Medicine (F.S.S.), Center for Immunology and Immune Mediated Diseases (S.C.H., F.S.S., F.M.A.), and Abboud Cardiovascular Research Center (S.C.H., J.R., M.W.C., F.M.A.), University of Iowa Carver College of Medicine, Iowa City. sailesh-harwani@uiowa.edu.
Jason RatcliffFrom the Department of Internal Medicine (S.C.H., J.R., F.S.S., Z.K.B., M.W.C., F.M.A.), Departments of Molecular Physiology and Biophysics (M.W.C., F.M.A.), and Veterans Affairs Medical Center (F.S.S., Z.K.B., M.W.C.), Iowa City; and Department of Pathology (D.K.M.), Inflammation Program, Department of Internal Medicine (F.S.S.), Center for Immunology and Immune Mediated Diseases (S.C.H., F.S.S., F.M.A.), and Abboud Cardiovascular Research Center (S.C.H., J.R., M.W.C., F.M.A.), University of Iowa Carver College of Medicine, Iowa City.
Fayyaz S SutterwalaFrom the Department of Internal Medicine (S.C.H., J.R., F.S.S., Z.K.B., M.W.C., F.M.A.), Departments of Molecular Physiology and Biophysics (M.W.C., F.M.A.), and Veterans Affairs Medical Center (F.S.S., Z.K.B., M.W.C.), Iowa City; and Department of Pathology (D.K.M.), Inflammation Program, Department of Internal Medicine (F.S.S.), Center for Immunology and Immune Mediated Diseases (S.C.H., F.S.S., F.M.A.), and Abboud Cardiovascular Research Center (S.C.H., J.R., M.W.C., F.M.A.), University of Iowa Carver College of Medicine, Iowa City.
Zuhair K BallasFrom the Department of Internal Medicine (S.C.H., J.R., F.S.S., Z.K.B., M.W.C., F.M.A.), Departments of Molecular Physiology and Biophysics (M.W.C., F.M.A.), and Veterans Affairs Medical Center (F.S.S., Z.K.B., M.W.C.), Iowa City; and Department of Pathology (D.K.M.), Inflammation Program, Department of Internal Medicine (F.S.S.), Center for Immunology and Immune Mediated Diseases (S.C.H., F.S.S., F.M.A.), and Abboud Cardiovascular Research Center (S.C.H., J.R., M.W.C., F.M.A.), University of Iowa Carver College of Medicine, Iowa City.
David K MeyerholzFrom the Department of Internal Medicine (S.C.H., J.R., F.S.S., Z.K.B., M.W.C., F.M.A.), Departments of Molecular Physiology and Biophysics (M.W.C., F.M.A.), and Veterans Affairs Medical Center (F.S.S., Z.K.B., M.W.C.), Iowa City; and Department of Pathology (D.K.M.), Inflammation Program, Department of Internal Medicine (F.S.S.), Center for Immunology and Immune Mediated Diseases (S.C.H., F.S.S., F.M.A.), and Abboud Cardiovascular Research Center (S.C.H., J.R., M.W.C., F.M.A.), University of Iowa Carver College of Medicine, Iowa City.
Mark W ChapleauFrom the Department of Internal Medicine (S.C.H., J.R., F.S.S., Z.K.B., M.W.C., F.M.A.), Departments of Molecular Physiology and Biophysics (M.W.C., F.M.A.), and Veterans Affairs Medical Center (F.S.S., Z.K.B., M.W.C.), Iowa City; and Department of Pathology (D.K.M.), Inflammation Program, Department of Internal Medicine (F.S.S.), Center for Immunology and Immune Mediated Diseases (S.C.H., F.S.S., F.M.A.), and Abboud Cardiovascular Research Center (S.C.H., J.R., M.W.C., F.M.A.), University of Iowa Carver College of Medicine, Iowa City.
Francois M AbboudFrom the Department of Internal Medicine (S.C.H., J.R., F.S.S., Z.K.B., M.W.C., F.M.A.), Departments of Molecular Physiology and Biophysics (M.W.C., F.M.A.), and Veterans Affairs Medical Center (F.S.S., Z.K.B., M.W.C.), Iowa City; and Department of Pathology (D.K.M.), Inflammation Program, Department of Internal Medicine (F.S.S.), Center for Immunology and Immune Mediated Diseases (S.C.H., F.S.S., F.M.A.), and Abboud Cardiovascular Research Center (S.C.H., J.R., M.W.C., F.M.A.), University of Iowa Carver College of Medicine, Iowa City.
Veterans Health Administration · US
Funding
VASOPRESSIN IN CARDIOVASCULAR REGULATIONP01HL014388 · NHLBI · UNIVERSITY OF IOWA · PI ABBOUD, FRANCOIS M · 1985 to 2018
$40.3MINTERDISCIPLINARY CARDIOVASCULAR RESEARCH FELLOWSHIPT32HL007121 · NHLBI · UNIVERSITY OF IOWA · PI LONDON, BARRY · 1985 to 2020
$15.1MTRAINING IN THE PATHOGENESIS OF INFECTIOUS DISEASEST32AI007517 · NIAID · YALE UNIVERSITY · PI Jaimie Meyer, Albert C Shaw · 1997 to 2026
$6.1MThe Neuro-Immuno Axis in a Genetic Model of HypertensionK08HL119588 · NHLBI · UNIVERSITY OF IOWA · PI HARWANI, SAILESH · 2014 to 2018
$733kNHLBI NIH HHS K08 HL119588NHLBI NIH HHS L30 HL134111NHLBI NIH HHS P01 HL014388NHLBI NIH HHS T32 HL007121NIAID NIH HHS T32 AI007517
Abstract
rationaleRenal inflammation contributes to the pathophysiology of hypertension. CD161a
objectiveWe aimed to phenotype CD161a METHODS AND
resultsStudies used young SHR and WKY (Wistar-Kyoto) rats. Splenocytes and bone marrow cells were exposed to nicotine ex vivo, and nicotine was infused in vivo. Blood pressures, kidney, serum, and urine were obtained. Flow cytometry, Luminex/ELISA, immunohistochemistry, confocal microscopy, and Western blot were used. Nicotinic cholinergic activation induced proliferation of CD161a
conclusionsA novel, inherited nicotinic cholinergic inflammatory effect exists in young SHR, measured by expansion of CD161a
Indexed as
Age of Onsetalpha7 Nicotinic Acetylcholine ReceptorAngiotensin IIAnimalsAntigens, CDAntigens, Differentiation, MyelomonocyticCD68 MoleculeCell MovementCells, CulturedChemokine CCL2CytokinesDenervationGene Expression RegulationHypertensionHypertension, RenalImmunophenotypingalpha7 Nicotinic Acetylcholine ReceptorAngiotensin IIAntigens, CDAntigens, Differentiation, MyelomonocyticCcl2 protein, mouseCD68 MoleculeCD68 protein, mouseChemokine CCL2CytokinesIntegrin alpha4beta1LectinsLLT1 protein, mouseNicotineNK Cell Lectin-Like Receptor Subfamily BNorepinephrineReceptor, Angiotensin, Type 1Receptor, Angiotensin, Type 2CD161CD68cholinergichypertensioninflammationinnate immunityintegrinlectinmacrophagenicotinerenalSHR
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