ArticleCirculation research2016
The High Blood Pressure-Malaria Protection Hypothesis.
Article in Circulation research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Prevalence of Cardiovascular Complications in Malaria: A Systematic Review and Meta-Analysis.The American journal of tropical medicine and hygiene · 2021Pooled it
- Investigating angiotensin II concentration in modulatingFrontiers in parasitology · 2026Article
- Hepcidin: A missing link at the interface of malaria and hypertension.IJID regions · 2024Review
- Immune and inflammatory mechanisms in hypertension.Nature reviews. Cardiology · 2024Review
- Genetic Variants within SARS-CoV-2 Human Receptor Genes May Contribute to Variable Disease Outcomes in Different Ethnicities.International journal of molecular sciences · 2023Review
- Beauty and the beast: host microRNA-155 versus SARS-CoV-2.Human cell · 2023Review
- Left ventricular function by strain in uncomplicated malaria: a prospective study from the Brazilian Amazon.The international journal of cardiovascular imaging · 2023Article
- Evolutionary trilogy of malaria, angiotensin II and hypertension: deeper insights and the way forward.Journal of human hypertension · 2022Review
- Low incidence of COVID-19 case severity and mortality in Africa; Could malaria co-infection provide the missing link?BMC infectious diseases · 2022Review
- The striking mimics between COVID-19 and malaria: A review.Frontiers in immunology · 2022Review
- Age and genotype dependent erythropoietin protection in COVID-19.World journal of stem cells · 2021Review
- Heart failure associated with imported malaria: a nationwide Danish cohort study.ESC heart failure · 2021Article
- Malaria, COVID-19 and angiotensin-converting enzyme 2: what does the available population data say?Open biology · 2021Review
- Elevated Levels of the Endothelial Molecules ICAM-1, VEGF-A, and VEGFR2 in Microscopic Asymptomatic Malaria.Open forum infectious diseases · 2021Article
- Malaria link of hypertension: a hidden syndicate of angiotensin II, bradykinin and sphingosine 1-phosphate.Human cell · 2021Review
- Disentangling the Coronavirus Disease 2019 Health Disparities in African Americans: Biological, Environmental, and Social Factors.Open forum infectious diseases · 2021Review
- How Genetics Might Explain the Unusual Link Between Malaria and COVID-19.Frontiers in medicine · 2021Article
- Interlinking Antecedent Malaria and Hypertension Through Angiotensin II in India.Frontiers in cardiovascular medicine · 2021Article
- Hypertension is associated with an increased risk for severe imported falciparum malaria: a tertiary care hospital based observational study from Berlin, Germany.Malaria journal · 2019Observational
- Epidemiological links between malaria parasitaemia and hypertension: findings from a population-based survey in rural Côte d'Ivoire.Journal of hypertension · 2019Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
rationaleA recently proposed hypothesis states that malaria may contribute to hypertension in endemic areas,
objectiveTo discuss a possible alternative cause for hypertension in populations who have been under the selective pressure of malaria. METHODS AND
resultsWe reviewed published scientific literature for studies that could establish a link between Ang II and malaria. Both genetic and functional studies suggested that high levels of Ang II may confer protection against cerebral malaria by strengthening the integrity of the endothelial brain barrier. We also describe strong experimental evidence supporting our hypothesis through genetic, functional, and interventional studies.
conclusionsA causal association between high levels of Ang II and protection from malaria pathogenesis can provide a likely explanation for the increased prevalence in hypertension observed in populations of African and South Asian origin. Furthermore, this potential causative connection might also direct unique approaches for the effective treatment of cerebral malaria.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.