Evidence map›Paper›PMID 27660281›Full record

ArticleAbdominal radiology (New York)2017

Detection of exocrine dysfunction by MRI in patients with early chronic pancreatitis.

Temel Tirkes, Evan L Fogel, Stuart Sherman, Chen Lin, Jordan Swensson, Fatih Akisik, Kumaresan Sandrasegaran

Open access · greenAbstract read
In one paragraph

Article in Abdominal radiology (New York), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
5.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 69 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Review
  7. T1 Mapping of the Abdomen, From theAJR. American journal of roentgenology · 2025
    Review
  8. Article
  9. Review
  10. Advances in MRI of Chronic Pancreatitis.Advances in clinical radiology · 2024
    Article
  11. Cross-sectional imaging of the pancreas in diabetes.Abdominal radiology (New York) · 2024
    Review
  12. Review
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Temel TirkesDepartment of Radiology and Clinical Sciences, Indiana University School of Medicine, 550 N. University Blvd. Suite 0663, Indianapolis, IN, 46202, USA. atirkes@iupui.edu.
Evan L FogelDivision of Gastroenterology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Stuart ShermanDivision of Gastroenterology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Chen LinDepartment of Radiology and Clinical Sciences, Indiana University School of Medicine, 550 N. University Blvd. Suite 0663, Indianapolis, IN, 46202, USA.
Jordan SwenssonDepartment of Radiology and Clinical Sciences, Indiana University School of Medicine, 550 N. University Blvd. Suite 0663, Indianapolis, IN, 46202, USA.
Fatih AkisikDepartment of Radiology and Clinical Sciences, Indiana University School of Medicine, 550 N. University Blvd. Suite 0663, Indianapolis, IN, 46202, USA.
Kumaresan SandrasegaranDepartment of Radiology and Clinical Sciences, Indiana University School of Medicine, 550 N. University Blvd. Suite 0663, Indianapolis, IN, 46202, USA.
Indiana University School of MedicineIndiana University – Purdue University Indianapolis · US

Funding

Indiana University (IU) Clinical Center for Chronic Pancreatitis Clinical Research NetworkU01DK108323 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Jeffrey James Easler, Evan L Fogel · 2015 to 2026
$6.5M
NIDDK NIH HHS U01 DK108323
6 · The paper itself

Abstract

purposeTo determine if T1-weighted MR signal of the pancreas can be used to detect early CP.

methodsA retrospective analysis was performed on 51 suspected CP patients, who had both secretin-enhanced magnetic resonance cholangiopancreatography (S-MRCP) and an intraductal secretin stimulation test (IDST). There were 29 patients in normal and 22 patients in the low bicarbonate group. Bicarbonate level, total pancreatic juice volume, and excretory flow rate were recorded during IDST. Signal intensity ratio of pancreas (SIR), fat signal fraction, pancreatograms findings, and grade of duodenal filling were recorded on S-MRCP by two blinded radiologists.

resultsThere was a significant difference in the signal intensity ratio of the pancreas to spleen (SIR

conclusionT1-weighted MR signal of the pancreas has a high sensitivity and specificity for the detection of parenchymal abnormalities related to exocrine dysfunction and can therefore be helpful in evaluation of suspected early CP.

Indexed as

Cholangiopancreatography, Magnetic ResonanceAdultAgedBicarbonatesFemaleHumansMaleMiddle AgedPancreatic JuicePancreatitis, ChronicRetrospective StudiesSecretinSensitivity and SpecificityBicarbonatesSecretinChronic pancreatitisDysfunctionExocrineMagnetic resonance imagingSecretin stimulation test

Identifiers

PMID27660281
PMCPMC5542580
OpenAlexW2523335811

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.