Evidence map›Paper›PMID 27660232›Full record

ArticleEuropean journal of nutrition2018

Rice bran protein hydrolysates reduce arterial stiffening, vascular remodeling and oxidative stress in rats fed a high-carbohydrate and high-fat diet.

Ketmanee Senaphan, Weerapon Sangartit, Poungrat Pakdeechote, Veerapol Kukongviriyapan, Patchareewan Pannangpetch, Supawan Thawornchinsombut, Stephen E Greenwald, Upa Kukongviriyapan

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In one paragraph

Article in European journal of nutrition, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

  1. Pooled it
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  3. Review
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  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. Antihypertensive Effect and Safety Evaluation of Rice Bran Hydrolysates from Sang-Yod Rice.Plant foods for human nutrition (Dordrecht, Netherlands) · 2020
    Article
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Ketmanee SenaphanDepartment of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand.
Weerapon SangartitDepartment of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand.
Poungrat PakdeechoteDepartment of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand.
Veerapol KukongviriyapanDepartment of Pharmacology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand.
Patchareewan PannangpetchDepartment of Pharmacology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand.
Supawan ThawornchinsombutDepartment of Food Technology, Faculty of Technology, Khon Kaen University, Khon Kaen, 40002, Thailand.
Stephen E GreenwaldBlizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, E1 2ES, UK.
Upa KukongviriyapanDepartment of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand. upa_ku@kku.ac.th.
Khon Kaen University · THQueen Mary University of London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeRice bran protein hydrolysates (RBPH) contain highly nutritional proteins and antioxidant compounds which show benefits against metabolic syndrome (MetS). Increased arterial stiffness and the components of MetS have been shown to be associated with an increased risk of cardiovascular disease. This study aimed to investigate whether RBPH could alleviate the metabolic disorders, arterial stiffening, vascular remodeling, and oxidative stress in rats fed a high-carbohydrate and high-fat (HCHF) diet.

methodsMale Sprague-Dawley rats were fed either a standard chow and tap water or a HCHF diet and 15 % fructose solution for 16 weeks. HCHF rats were treated orally with RBPH (250 or 500 mg/kg/day) for the final 6 weeks of the experimental period.

resultsRats fed with HCHF diet had hyperglycemia, insulin resistance, dyslipidemia, hypertension, increased aortic pulse wave velocity, aortic wall hypertrophy and vascular remodeling with increased MMP-2 and MMP-9 expression. RBPH supplementation significantly alleviated these alterations (P < 0.05). Moreover, RBPH reduced the levels of angiotensin-converting enzyme (ACE) and tumor necrosis factor-alpha in plasma. Oxidative stress was also alleviated after RBPH treatment by decreasing plasma malondialdehyde, reducing superoxide production and suppressing p47

conclusionRBPH mitigate the deleterious effects of HCHF through potential mechanisms involving enhanced NO bioavailability, anti-ACE, anti-inflammatory and antioxidant properties. RBPH could be used as dietary supplements to minimize oxidative stress and vascular alterations triggered by MetS.

Indexed as

Angiotensin-Converting Enzyme InhibitorsAnimalsAnti-Inflammatory AgentsAntioxidantsDietary CarbohydratesDiet, High-FatMaleMetabolic SyndromeOryzaOxidative StressPlant ProteinsProtein HydrolysatesRatsRats, Sprague-DawleySeedsVascular RemodelingAngiotensin-Converting Enzyme InhibitorsAnti-Inflammatory AgentsAntioxidantsDietary CarbohydratesPlant ProteinsProtein HydrolysatesArterial stiffnessHigh-carbohydrate and high-fat dietMetabolic syndromeOxidative stressRice bran protein hydrolysatesVascular remodeling

Identifiers

PMID27660232
OpenAlexW2521238759

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.