ArticleWorld journal of microbiology & biotechnology2016
Aspergillus fumigatus DBM 4057 biofilm formation is inhibited by chitosan, in contrast to baicalein and rhamnolipid.
Article in World journal of microbiology & biotechnology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 31 citations in OpenAlex.
- Antimicrobial effects and mechanism of action of carboxymethyl chitosan-loaded silver ion complexes against drug-resistant Aspergillus fumigatus.Journal of microbiology (Seoul, Korea) · 2026Article
- Isoferulic acid suppressesFrontiers in microbiology · 2026Article
- The antibacterial activity, action mechanisms and prospects of Baicalein as an antibacterial adjuvant.World journal of microbiology & biotechnology · 2025Review
- Baicalein and Berberine Inhibit the Growth and Virulence ofPathogens (Basel, Switzerland) · 2025Article
- Study of the antagonistic relationship between gene expression biofilm ofCurrent medical mycology · 2024Article
- Antifungal Activity of Chitosan againstJournal of fungi (Basel, Switzerland) · 2023Article
- Antifungal effect of triclosan on Aspergillus fumigatus: quorum quenching role as a single agent and synergy with liposomal amphotericin-B.World journal of microbiology & biotechnology · 2022Article
- Clinical Presentations, Cluster Analysis and Laboratory-Based Investigation ofJournal of fungi (Basel, Switzerland) · 2022Article
- Low-molecular weight chitosan enhances antibacterial effect of antibiotics and permeabilizes cytoplasmic membrane of Staphylococcus epidermidis biofilm cells.Folia microbiologica · 2021Article
- Natural antioxidant pterostilbene as an effective antibiofilm agent, particularly for gram-positive cocci.World journal of microbiology & biotechnology · 2020Article
- Calcineurin signaling pathway influencesBiotechnology for biofuels · 2020Article
- Molecular Mechanisms of Chitosan Interactions with Fungi and Plants.International journal of molecular sciences · 2019Review
- Synergistic antifungal effect of chitosan-stabilized selenium nanoparticles synthesized by pulsed laser ablation in liquids againstInternational journal of nanomedicine · 2018Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The biofilms of filamentous-forming fungi are a novel and still insufficiently understood research topic. We have studied Aspergillus fumigatus, an ubiquitous opportunistic pathogenic fungus, as a representative model for a study of biofilm formation by filamentous fungi and for assessing the potential anti-biofilm activity of natural substances. The activity of antibiotic amphotericin B and selected natural substances: baicalein, chitosan and rhamnolipid was studied. The minimum suspension inhibitory concentrations (MIC) were determined and the biofilm susceptibility was investigated by determining the metabolic activity of sessile cells (XTT assay) and total biofilm biomass (crystal violet staining). Significant time-dependent differences in substances' anti-biofilm activity were observed. Images of A. fumigatus biofilm were obtained by Cellavista automatic light microscope and spinning disc confocal microscopy. Baicalein and rhamnolipid were not found as suitable substances for inhibition of the A. fumigatus biofilm formation, as neither of the substances inhibited the sessile cells metabolic activity or the total biofilm biomass even at tenfold MIC after 48 h. In contrast, chitosan at 10 × MIC (25 µg mL
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