ArticleMedical molecular morphology2017
Expression and localization of forkhead box protein FOXJ1 in S100β-positive multiciliated cells of the rat pituitary.
Article in Medical molecular morphology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 10 citations in OpenAlex.
- Loss of primary cilia in late pituitary organogenesis does not cause endocrine dysfunction.Journal of anatomy · 2026Article
- TGFβ signaling regulates Col15a1 expression in fenestrated endothelial cells of the rat pituitary.Cell and tissue research · 2026Article
- Regulation of Aqp1 expression by osmotic balance in fenestrated endothelial cells of the posterior lobe of the pituitary.Cell and tissue research · 2025Article
- Article
- Crystal structure of human PACRG in complex with MEIG1 reveals roles in axoneme formation and tubulin binding.Structure (London, England : 1993) · 2021Article
- Fibronectin-integrin signaling regulates PLVAP localization at endothelial fenestrae by microtubule stabilization.Cell and tissue research · 2021Article
- Fibronectin is essential for formation of fenestrae in endothelial cells of the fenestrated capillary.Cell and tissue research · 2021Article
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Authors and funding
12 authors at 5 institutions in 1 country.
Funding
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Abstract
S100β-positive cells exist in the marginal cell layer (MCL) of the adenohypophysis and follicle structure in the parenchyma of anterior lobe (ALFS) in pituitary. They have multiple functions as phagocytes or cells that regulate hormone secretion. Majority of S100β-positive cells in the adenohypophysis express sex determining region Y-box 2 protein (SOX2), a stem cell marker; therefore, S100β/SOX2 double positive cells are also considered as one type of stem/progenitor cells. MCL and ALFS are consisting of morphologically two types of cells, i.e., multiciliated cells and non-ciliated cells. However, the relationship between the S100β-positive cells and multiciliated cells in the pituitary is largely unknown. In the present study, we first immunohistochemically verified the feature of multiciliated cells in MCL and ALFS. We then examined the expression patterns of FOXJ1, an essential expression factor for multiciliated cell-differentiation, and SOX2 in the S100β-positive multiciliated cells by in situ hybridization and immunohistochemistry. We identified anew the S100β/SOX2/FOXJ1 triple positive multiciliated cells, and revealed that they were dispersed throughout the MCL and ALFS. These results indicate that the MCL and ALFS are consisting of morphologically and functionally distinct two types of cells, i.e., S100β/SOX2 double positive non-ciliated cells and S100β/SOX2/FOXJ1 triple positive multiciliated cells.
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