ArticlePlant physiology2016
Identification of Homogentisate Dioxygenase as a Target for Vitamin E Biofortification in Oilseeds.
Article in Plant physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 59 citations in OpenAlex.
- Review
- A century of vitamin E research: The innovative journey from basic biology to synthetic bio-manufacturing.Journal of integrative plant biology · 2026Review
- Molecular polymorphisms that underlie trait variation in crops: Lessons learned from soybean.The plant genome · 2026Review
- Transcriptional landscape of Atractylodes chinensis contracting root rot.BMC plant biology · 2025Article
- Gene Localization and Functional Validation ofPlants (Basel, Switzerland) · 2025Article
- Vitamin E in Plants: Biosynthesis Pathways, Biofortification Strategies, and Regulatory Dynamics.International journal of molecular sciences · 2025Review
- Soybean genomics research community strategic plan: A vision for 2024-2028.The plant genome · 2024Article
- Whole-genome sequencing of tetraploid potato varieties reveals different strategies for drought tolerance.Scientific reports · 2024Article
- HarnessingAntioxidants (Basel, Switzerland) · 2024Article
- Overexpression of the potatoFrontiers in plant science · 2024Article
- Genome-wide association study and genotypic variation for the major tocopherol content in rice grain.Frontiers in plant science · 2024Article
- Vitamin E biofortification: enhancement of seed tocopherol concentrations by altered chlorophyll metabolism.Frontiers in plant science · 2024Article
- Critical role for uricase and xanthine dehydrogenase in soybean nitrogen fixation and nodule development.The plant genome · 2023Article
- Review
- Biochemical, Histological, and Ultrastructural Studies of the Protective Role of Vitamin E on Cyclophosphamide-Induced Cardiotoxicity in Male Rats.Biomedicines · 2023Article
- Ectopic expression of a rice triketone dioxygenase gene confers mesotrione tolerance in soybean.Pest management science · 2022Article
- Vitamin E synthesis and response in plants.Frontiers in plant science · 2022Review
- Geographic distribution of the E1 family of genes and their effects on reproductive timing in soybean.BMC plant biology · 2021Article
- Article
- Role of cytosolic, tyrosine-insensitive prephenate dehydrogenase inPlant direct · 2020Article
Corrections and comments
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Authors and funding
16 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Soybean (Glycine max) is a major plant source of protein and oil and produces important secondary metabolites beneficial for human health. As a tool for gene function discovery and improvement of this important crop, a mutant population was generated using fast neutron irradiation. Visual screening of mutagenized seeds identified a mutant line, designated MO12, which produced brown seeds as opposed to the yellow seeds produced by the unmodified Williams 82 parental cultivar. Using forward genetic methods combined with comparative genome hybridization analysis, we were able to establish that deletion of the GmHGO1 gene is the genetic basis of the brown seeded phenotype exhibited by the MO12 mutant line. GmHGO1 encodes a homogentisate dioxygenase (HGO), which catalyzes the committed enzymatic step in homogentisate catabolism. This report describes to our knowledge the first functional characterization of a plant HGO gene, defects of which are linked to the human genetic disease alkaptonuria. We show that reduced homogentisate catabolism in a soybean HGO mutant is an effective strategy for enhancing the production of lipid-soluble antioxidants such as vitamin E, as well as tolerance to herbicides that target pathways associated with homogentisate metabolism. Furthermore, this work demonstrates the utility of fast neutron mutagenesis in identifying novel genes that contribute to soybean agronomic traits.
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