Evidence map›Paper›PMID 27660076›Full record

ArticleNeurobiology of learning and memory2016

Impaired function of α2-containing nicotinic acetylcholine receptors on oriens-lacunosum moleculare cells causes hippocampus-dependent memory impairments.

Elise Kleeman, Sakura Nakauchi, Hailing Su, Richard Dang, Marcelo A Wood, Katumi Sumikawa

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of learning and memory, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Enhanced Sensory-Cognitive Processing by Activation of Nicotinic Acetylcholine Receptors.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2019
    Review
  7. Combined acupuncture andNeural regeneration research · 2018
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Elise KleemanDepartment of Neurobiology and Behavior, University of California Irvine, Irvine, CA 92697-4550, USA.
Sakura NakauchiDepartment of Neurobiology and Behavior, University of California Irvine, Irvine, CA 92697-4550, USA.
Hailing SuDepartment of Neurobiology and Behavior, University of California Irvine, Irvine, CA 92697-4550, USA.
Richard DangDepartment of Neurobiology and Behavior, University of California Irvine, Irvine, CA 92697-4550, USA.
Marcelo A WoodDepartment of Neurobiology and Behavior, University of California Irvine, Irvine, CA 92697-4550, USA.
Katumi SumikawaDepartment of Neurobiology and Behavior, University of California Irvine, Irvine, CA 92697-4550, USA. Electronic address: ksumikaw@uci.edu.
University of California, Irvine · US

Funding

Role of Neuron-Specific Nucleosome Remodeling in Intellectual DisabilityR01MH101491 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI LYNCH, GARY S, WOOD, MARCELO ANDRES · 2013 to 2017
$2.3M
Maternal nicotine exposure and development of hippocampal circuitsR01DA026458 · NIDA · UNIVERSITY OF CALIFORNIA-IRVINE · PI SUMIKAWA, KATUMI · 2009 to 2013
$1.7M
Coordinate gene expression via nucleosome remodeling and chromosomal loopingR01DA036984 · NIDA · UNIVERSITY OF CALIFORNIA-IRVINE · PI AKBARIAN, SCHAHRAM, WOOD, MARCELO ANDRES · 2013 to 2016
$1.5M
Mechanisms of nicotine-induced neuroplasticityR01DA025676 · NIDA · UNIVERSITY OF CALIFORNIA-IRVINE · PI SUMIKAWA, KATUMI · 2010 to 2014
$1.5M
Maternal smoking and hippocampal circuitsR21DA025269 · NIDA · UNIVERSITY OF CALIFORNIA-IRVINE · PI SUMIKAWA, KATUMI · 2009 to 2010
$421k
Histone Deacetylases: Regulators of Cocaine Reward and Targets for TherapeuticsR21DA031989 · NIDA · UNIVERSITY OF CALIFORNIA-IRVINE · PI WOOD, MARCELO ANDRES · 2011 to 2012
$421k
NIDA NIH HHS R01 DA025676NIDA NIH HHS R01 DA026458NIDA NIH HHS R01 DA036984NIDA NIH HHS R21 DA025269NIDA NIH HHS R21 DA031989NIMH NIH HHS R01 MH101491
6 · The paper itself

Abstract

Children of mothers who smoked during pregnancy are at significantly greater risk for cognitive impairments including memory deficits, but the mechanisms underlying this effect remain to be understood. In rodent models of smoking during pregnancy, early postnatal nicotine exposure results in impaired long-term hippocampus-dependent memory, functional loss of α2-containing nicotinic acetylcholine receptors (α2

Indexed as

Memory DisordersPrenatal Exposure Delayed EffectsAnimalsAnimals, NewbornBehavior, AnimalCA1 Region, HippocampalDisease Models, AnimalFemaleInterneuronsLong-Term PotentiationMice, Inbred C57BLMice, KnockoutNicotineNicotinic AgonistsPregnancyReceptors, NicotinicNicotineNicotinic AgonistsReceptors, NicotinicLong-term potentiationNicotine exposureObject location memoryObject recognition memorySchaffer collateral pathway

Identifiers

PMID27660076
PMCPMC5124391
OpenAlexW2521832268

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.